Cluster Randomised Trials

Cluster Randomised Trials, 2nd Edition, by Richard J. Hayes and Lawrence H. Moulton, examines the design, conduct, and analysis of trials that allocate groups of individuals to different treatments. Published by Chapman & Hall, the book focuses on medical and public health applications, with particular attention to assessing interventions against infectious diseases.

Avoiding unnecessary mathematical detail, the text outlines core concepts of cluster randomisation, including direct, indirect, and total effects. It also reviews the decision to randomise by cluster and introduces both cluster-level summaries and individual-level regression analyses.

Intended for students, clinical trials practitioners, and methodologists, the book encourages readers to reproduce the included analyses and adapt the methods to their own trials.