Fundamentals and Design of Drug Delivery Systems
A Textbook with Lab Activities
by Wujie Zhang
1st Edition
Publisher: Academic Press
Book Details
| Print ISBN | 9780443235214 |
| eText ISBN | 9780443235207 |
| Publisher | Academic Press |
| Publishing Year | 2025 |
| Edition | 1st Edition |
| Language | English |
| Pages | 390 |
Fundamentals and Design of Drug Delivery Systems, 1st Edition provides a thorough academic foundation connecting classic pharmacological principles to modern carrier design. Intended for upper-undergraduate and graduate courses in pharmaceutical sciences and engineering, this textbook demonstrates how active therapeutic agents interact with biological environments while navigating anatomical and biochemical barriers.
The text begins with historical pharmacy background, basic pharmacology, pharmacokinetics, and pharmacodynamics before detailing physiological barriers to drug transport. Subsequent chapters explore specific delivery mechanisms, examining targeted release, site-specific delivery, diffusion-controlled systems, erodible constructs, and osmotic delivery methods. Each topic highlights physical and chemical factors influencing controlled release behavior.
To support practical learning, integrated laboratory activities and end-of-chapter review and practice questions guide students through experimental design procedures and data analysis. This approach equips upper-undergraduate students, master's candidates, and PhD researchers in pharmaceutical engineering with clear methodology for designing delivery systems.
Table of Contents
Chapter 1: Introduction
- • 1.1 Drug Delivery and Drug Delivery Systems
- • 1.2 The Promise of Novel Drug Delivery Systems
- • 1.3 The Layout of the Textbook
- • 1.4 Resources for Studying Drug Delivery
- • Lab Activity I: Delivery of nucleic acids into Cells Using Cationic Lipids
- • Review and Practice Questions
- • References
Chapter 2: Historical Aspects of Pharmacy and Delivery of Drugs
- • 2.1 Historical Aspects of Drugs, Pharmacy, and Pharmacy Education
- • 2.2 Historical Aspects of Drug Delivery
- • Review and Practice Questions
- • References
Chapter 3: Basics of Pharmacology, Pharmacokinetics and Pharmacodynamics
- • 3.1 Introduction to Pharmacology, Pharmacokinetics and Pharmacodynamics
- • 3.2 Drug Actions on Living Organisms
- • 3.3 Termination of Drug Actions: Excretion and Biotransformation
- • 3.4 Pharmacokinetics
- • 3.5 Factors Influence the Drug Effects
- • Case Study I
- • Lab Activity II: Drug Stability
- • Review and Practice Questions
- • References
Chapter 4: Physiological and Biochemical Barriers to Drug Delivery
- • 4.1 Process of Drug Absorption
- • 4.2 Physiological Barriers to Peroral Drug Delivery
- • 4.3 First-pass metabolism
- • 4.4 Physiological Barriers to Non-peroral Drug Delivery
- • 4.5 Biochemical Barriers to Drug Delivery
- • 4.6 Immune System and Drug Delivery Systems
- • 4.7 Novel Models for Drug Testing
- • Case Study II
- • Sample and Practice Questions
- • References
Chapter 5: Prodrugs as Drug Delivery Systems
- • 5.1 Introduction to Prodrugs
- • 5.2 Principles of Prodrug Design
- • 5.3 Advances in Prodrugs as Drug Delivery Systems
- • 5.4 New Prodrugs in Therapy
- • Case Study III
- • Review and Practice Questions
- • References
Chapter 6: Engineered Carriers in Drug Delivery
- • 6.1 Materials for Drug Carriers
- • 6.2 Microscale Drug Carriers
- • 6.3 Nanoscale Drug Carriers
- • 6.4 Design and Modify Drug Carriers
- • Lab Activity III: Natural Biopolymer Purification
- • Lab Activity IV: Microscale Carrier Preparation: Hydrogel Microspheres
- • Lab Activity V: Nanoscale Carrier Preparation: Metallic Nanoparticles
- • Review and Practice Questions
- • References
Chapter 7: Cell Encapsulation – A Living Drug Delivery Approach
- • 7.1 Introduction to Cell Encapsulation and Microencapsulation
- • 7.2 Cell Microencapsulation Methods
- • 7.3 Cell Encapsulation in Therapy
- • Case Study IV
- • Lab Activity VI: Cell (Micro)Encapsulation in Hydrogel
- • Review and Practice Questions
- • References
Chapter 8: Diffusion-Controlled Drug Delivery Systems
- • 8.1 Diffusion Theory
- • 8.2 Reservoir Systems
- • 8.3 Matrix Systems
- • 8.4 Design of Diffusion-Controlled Drug Delivery Systems
- • Review and Practice Questions
- • References
Chapter 9: Erodible Drug Delivery Systems
- • 9.1 Introduction to Erosion
- • 9.2 Drug Release from the Erodible Drug Delivery Systems
- • 9.3 Design of Erodible Drug Delivery Systems
- • Lab Activity VII: Drug Release Profile Determination
- • Review and Practice Questions
- • References
Chapter 10: Osmotic-Controlled Drug Delivery Systems
- • 10.1 Osmosis
- • 10.2 Elementary Osmotic-Controlled Drug Delivery Systems
- • 10.3 Push-Pull Systems
- • 10.4 Design of Osmotic-Controlled Drug Delivery Systems
- • Case Study V
- • Review and Practice Questions
- • References
Chapter 11: Targeted Drug Delivery Systems
- • 11.1 Requirements for Effective Drug Targeting
- • 11.2 Design of Targeted Drug Delivery Systems: Targets and Ligands
- • 11.3 Design of Targeted Drug Delivery Systems: Physical Targeting
- • 11.4 Design of Targeted Drug Delivery Systems: Passive and Active Targeting
- • Review and Practice Questions
- • References
Chapter 12: Biomimetic Drug Delivery Systems
- • 12.1 Biomimicry
- • 12.2 Cell Membrane/Lipoprotein-Based Drug Delivery Systems
- • 12.3 Extracellular Vesicles-Based Drug Delivery Systems
- • 12.4 Design of Biomimetic Drug Delivery Systems
- • Review and Practice Questions
- • References
Chapter 13: Site-Specific Drug Delivery
- • 13.1 Drug Delivery to the Brain
- • 13.2 Drug Delivery to the Colon
- • 13.3 Drug Delivery in Cancer Therapy
- • Review and Practice Questions
- • References
Chapter 14: Stimuli-Responsive Drug Delivery Systems
- • 14.1 Internal and External Stimuli
- • 14.2 pH-Responsive Drug Delivery Systems
- • 14.3 Redox-Responsive Drug Delivery Systems
- • 14.4 Enzyme-Responsive Drug Delivery Systems
- • 14.5 External Stimuli-Based Drug Delivery Systems
- • 14.6 Design of Stimuli-Responsive Drug Delivery Systems
- • Case Study VI
- • Lab Activity VII: Stimuli-Responsive Drug Carriers
- • Review and Practice Questions
- • References
Chapter 15: Other Drug Delivery Systems
- • 15.1 Mucoadhesive Drug Delivery Systems
- • 15.2 Micro Nozzle Technology-Based Drug Delivery Systems
- • 15.3 Microrobots-Based Drug Delivery Systems
- • 15.4 Engineered Cells as Drug Delivery Systems
- • 15.5 Wireless On-Demand Drug Delivery Systems
- • 15.6 3D Printing-Based Drug Delivery Technology
- • 15.7 Artificial Intelligence (AI) in Drug Delivery
- • Review and Practice Questions
- • References
Chapter 16: Commercialization of Controlled Release Products
- • 16.1 Implementation of Quality by Design (QbD), Design of Experiments (DoE) and Process Analytical Technology (PAT)
- • 16.2 New Drug Development and Approval Process
- • 16.3 Recalls, Market Withdraws, and Safety Alerts
- • Review and Practice Questions
- • References
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