Holland-Frei Cancer Medicine
by Robert C. Bast Jr., John C. Byrd, Carlo M. Croce
10th Edition
Publisher: Wiley-Blackwell
Book Details
| Print ISBN | 9781119750680 |
| eText ISBN | 9781119750697 |
| Publisher | Wiley-Blackwell |
| Publishing Year | 2023 |
| Edition | 10th Edition |
| Language | English |
| Pages | 2000 |
Holland-Frei Cancer Medicine, 10th Edition, provides a comprehensive oncology reference that integrates cancer biology with clinical practice. Published in collaboration with the American Association for Cancer Research, the work details cancer science, disease mechanisms, and patient care.
The volume addresses epidemiology, etiology, tumor biology, immunology, prevention, pathology, imaging, and therapeutics. Readers examine topics such as cellular metabolism and tumor angiogenesis, linking foundational laboratory concepts with multidisciplinary cancer management.
Pedagogic features such as overview boxes and additional references assist readers navigating complex subjects. The text supports medical oncologists, radiation oncologists, internists, and allied health professionals seeking research-driven patient care.
Table of Contents
Chapter 1: Cardinal manifestations of cancer
Chapter 2: Biological hallmarks of cancer
Chapter 3: Molecular biology, genetics, and translational models of human cancer
Chapter 4: Oncogenes
Chapter 5: Tumor suppressor genes
Chapter 6: Epigenetic contributions to human cancer
Chapter 7: Cancer genomics and evolution
Chapter 8: Chromosomal aberrations in cancer
Chapter 9: MicroRNA expression in cancer
Chapter 10: Aberrant signaling pathways in cancer
Chapter 11: Differentiation therapy
Chapter 12: Cancer stem cells
Chapter 13: Cancer and cell death
Chapter 14: Cancer cell immortality: targeting telomerase and telomeres
Chapter 15: Cancer metabolism
Chapter 16: Tumor angiogenesis
Chapter 17: Cancer bioinformatics
Chapter 18: Systems biology and genomics
Chapter 19: Statistical innovations in cancer research
Chapter 20: Biomarker based clinical trial design in the era of genomic medicine
Chapter 21: Clinical and research informatics data strategy for precision oncology
Chapter 22: Chemical carcinogenesis
Chapter 23: Ionizing radiation
Chapter 24: Ultraviolet radiation carcinogenesis
Chapter 25: Inflammation and cancer
Chapter 26: RNA tumor viruses
Chapter 27: Herpesviruses
Chapter 28: Papillomaviruses and cervical neoplasia
Chapter 29: Hepatitis viruses and hepatoma
Chapter 30: Parasites
Chapter 31: Cancer epidemiology
Chapter 32: Hereditary cancer syndromes: risk assessment and genetic counseling
Chapter 33: Behavioral approaches to cancer prevention
Chapter 34: Diet and nutrition in the etiology and prevention of cancer
Chapter 35: Chemoprevention of cancer
Chapter 36: Cancer screening and early detection
Chapter 37: Clinical cancer genomic diagnostics and modern diagnostic pathology
Chapter 38: Molecular diagnostics in cancer
Chapter 39: Principles of imaging
Chapter 40: Interventional radiology for the cancer patient
Chapter 41: Principles of surgical oncology
Chapter 42: Principles of radiation oncology
Chapter 43: Principles of medical oncology
Chapter 44: Pain and palliative care
Chapter 45: Psycho-oncology
Chapter 46: Principles of cancer rehabilitation medicine
Chapter 47: Integrative oncology in cancer care
Chapter 48: Health services research
Chapter 49: Precision medicine in oncology drug development
Chapter 50: Drug development of small molecule cancer therapeutics in an Academic Cancer Center
Chapter 51: Principles of dose, schedule, and combination therapy
Chapter 52: Pharmacology of small-molecule anticancer agents
Chapter 53: Folate antagonists
Chapter 54: Pyrimidine and purine antimetabolites
Chapter 55: Alkylating agents and platinum antitumor compounds
Chapter 56: DNA topoisomerase targeting drugs
Chapter 57: Microtubule inhibitors
Chapter 58: Drug resistance and its clinical circumvention
Chapter 59: Cytokines, interferons, and hematopoietic growth factors
Chapter 60: Monoclonal antibody and targeted toxin therapy
Chapter 61: Vaccines and immunomodulators
Chapter 62: T cell immunotherapy of cancer
Chapter 63: Cancer immunotherapy
Chapter 64: Cancer gene therapy
Chapter 65: Cancer nanotechnology
Chapter 66: Hematopoietic cell transplantation
Chapter 67: Principles of pediatric oncology
Chapter 68: Cancer and pregnancy
Chapter 69: Cancer and aging
Chapter 70: Disparities in cancer care
Chapter 71: Neoplasms in people living with human immunodeficiency virus
Chapter 72: Cancer survivorship
Chapter 73: Primary neoplasms of the brain in adults
Chapter 74: Neoplasms of the eye and orbit
Chapter 75: Neoplasms of the endocrine glands and pituitary neoplasms
Chapter 76: Neoplasms of the thyroid
Chapter 77: Malignant tumors of the adrenal gland
Chapter 78: Tumors of the diffuse neuroendocrine and gastroenteropancreatic system
Chapter 79: Neoplasms of the head and neck
Chapter 80: Cancer of the lung
Chapter 81: Malignant pleural mesothelioma
Chapter 82: Thymomas and thymic tumors
Chapter 83: Tumors of the heart and great vessels
Chapter 84: Primary germ cell tumors of the thorax
Chapter 85: Neoplasms of the esophagus
Chapter 86: Carcinoma of the stomach
Chapter 87: Primary neoplasms of the liver
Chapter 88: Gallbladder and bile duct cancer
Chapter 89: Neoplasms of the exocrine pancreas
Chapter 90: Neoplasms of the appendix and peritoneum
Chapter 91: Carcinoma of the colon and rectum
Chapter 92: Neoplasms of the anus
Chapter 93: Renal cell carcinoma
Chapter 94: Urothelial cancer
Chapter 95: Neoplasms of the prostate
Chapter 96: Tumors of the penis and the urethra
Chapter 97: Testis cancer
Chapter 98: Neoplasms of the vulva and vagina
Chapter 99: Neoplasms of the cervix
Chapter 100: Endometrial cancer
Chapter 101: Epithelial ovarian, fallopian tube, and peritoneal cancer
Chapter 102: Nonepithelial ovarian malignancies
Chapter 103: Molar pregnancy and gestational trophoblastic neoplasia
Chapter 104: Gynecologic sarcomas
Chapter 105: Neoplasms of the breast
Chapter 106: Malignant melanoma
Chapter 107: Other skin cancers
Chapter 108: Bone tumors
Chapter 109: Soft tissue sarcomas
Chapter 110: Myelodysplastic syndromes
Chapter 111: Acute myeloid leukemia in adults: mast cell leukemia and other mast cell neoplasms
Chapter 112: Chronic myeloid leukemia
Chapter 113: Acute lymphoblastic leukemia
Chapter 114: Chronic lymphocytic leukemia
Chapter 115: Hodgkin lymphoma
Chapter 116: Clonal hematopoiesis in cancer
Chapter 117: Non-Hodgkin’s lymphoma
Chapter 118: Mycosis fungoides and Sézary syndrome
Chapter 119: Plasma cell disorders
Chapter 120: Myeloproliferative disorders
Chapter 121: Neoplasms of unknown primary site
Chapter 122: Cancer cachexia
Chapter 123: Antiemetic therapy
Chapter 124: Neurologic complications of cancer
Chapter 125: Dermatologic complications of cancer chemotherapy
Chapter 126: Skeletal complications
Chapter 127: Hematologic complications and blood bank support
Chapter 128: Coagulation complications of cancer patients
Chapter 129: Urologic complications related to cancer and its treatment
Chapter 130: Cardiac complications
Chapter 131: Respiratory complications
Chapter 132: Gastrointestinal and hepatic complications in cancer patients
Chapter 133: Oral complications of cancer and their treatment
Chapter 134: Gonadal complications
Chapter 135: Sexual dysfunction
Chapter 136: Endocrine complications and paraneoplastic syndromes
Chapter 137: Infections in patients with cancer
Chapter 138: Oncologic emergencies
Chapter 139: A vision for twenty-first century healthcare
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