Name: Imaging Blood-Brain Barrier Dysfunction in Brain Disorders
Price: 129 USD
Availability: InStock
ISBN: 9780443329746

Imaging Blood-Brain Barrier Dysfunction in Brain Disorders, 1st Edition, presents an examination of modern neuroimaging techniques used to evaluate vascular barrier integrity. Authors Danny J.J. Wang and Xingfeng Shao establish how diagnostic tools map normal barrier function alongside pathological alterations in central nervous system conditions.

The text systematically reviews foundational barrier biology and natural functional shifts. It details nuclear medicine approaches and water exchange magnetic resonance imaging designed to measure permeability across different physiological states, including variations connected to aging and circadian sleep patterns.

Subsequent chapters focus on imaging applications for specific neurological conditions, including stroke, traumatic brain injury, and cerebral small vessel disease. The volume offers structured technical explanations tailored for MRI technologists and neuroscientists analyzing vascular pathology.

Chapter 1: Biology of BBB
- • 1.1 Structure and function of BBB
- • 1.2 BBB and glymphatic system
- • 1.3 BBB variation with aging and circadian rhythm
Chapter 2: Imaging of BBB function
- • 2.1 Nuclear medicine approaches
- • 2.2 MRI measurement of BBB permeability
- • 2.3 MRI measurement of BBB water exchange
Chapter 3: Imaging natural variation of BBB function
- • 3.1 Imaging BBB function with aging and between genders
- • 3.2 Imaging BBB function during sleep
Chapter 4: Imaging BBB dysfunction in brain disorders
- • 4.1 Dementia (AD, PD etc)
- • 4.2 Stroke
- • 4.3 Cerebral small vessel disease (cSVD)
- • 4.4 Brain tumor
- • 4.5 Psychiatric diseases (Schizophrenia, depression etc)
Chapter 5: Imaging BBB for treating brain disorders
- • 5.1 Therapeutic targets and drug delivery across the BBB
- • 5.2 Transit BBB opening using focused ultrasound (FUS)
Chapter 6: Looking into the future
- • 6.1 Emerging technologies in BBB imaging (ultrahigh field)
- • 6.2 Challenges and opportunities in BBB research
- • 6.3 Ethical considerations and future directions in BBB studies