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Molecular Biology cover

Molecular Biology

Principles of Genome Function

by Nancy L. Craig, Rachel R. Green, Carol C. Greider, Gisela G. Storz, Cynthia Wolberger

3rd Edition

Publisher: Oxford University Press

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Book Details

Print ISBN9780198788652
eText ISBN9780192522795
PublisherOxford University Press
Publishing Year2021
Edition3rd Edition
LanguageEnglish
Pages912

The biological world operates across an astonishing range of scales, from microscopic molecules to expansive ecosystems. At the very center of this complexity lies the transmission and regulation of genetic information. Understanding how this static repository of genomic data transforms into dynamic cellular processes is the core mission of modern life sciences. Molecular Biology: Principles of Genome Function 3rd Edition addresses this fundamental question by offering a modern, integrated perspective on how molecular machinery collaborates to sustain life. In an era of rapid genomic discovery, this textbook provides an essential foundation for grasping the mechanisms that govern cellular behavior and biological diversity. It is a crucial resource for navigating contemporary biotechnology.

Rather than treating molecular mechanisms as isolated events, the authors structure their analysis around key unifying principles. This conceptual framework emphasizes the profound commonalities shared across the three domains of life, while carefully highlighting instructive differences that explain evolutionary diversity. By focusing on these conserved pathways, the text helps students build a cohesive mental model of cellular function. The narrative seamlessly integrates recurring themes, demonstrating how specific molecular phenomena influence genome behavior in diverse contexts. This holistic perspective ensures that readers do not simply memorize facts, but instead develop a deep, intuitive understanding of the living cell and its complex regulatory networks.

Designed for advanced undergraduate and graduate courses, this text is highly valued for its experimental focus. Distinctive Experimental Approach panels guide students through landmark research studies, illustrating how scientists actually uncover molecular truths. This pedagogical design is further enhanced by custom full-color artwork, comprehensive end-of-chapter summaries, and thought-provoking review questions. For those seeking a flexible digital learning option, the Molecular Biology: Principles of Genome Function 3rd Edition PDF offers convenient access to these rich resources. Ultimately, Molecular Biology: Principles of Genome Function 3rd Edition serves as an invaluable guide for the next generation of researchers preparing to tackle the unresolved questions of this rapidly evolving scientific discipline.

Table of Contents

  1. Chapter 1: Genomes and the flow of biological information

    • • The molecular basis of life
    • • The three domains of life
    • • Information flow in cells
  2. Chapter 2: DNA and RNA Structure

    • • Nucleic acid chemistry
    • • Double helix dynamics
    • • RNA secondary and tertiary structures
  3. Chapter 3: Genome Organization and Chromatin

    • • Nucleosomes and histones
    • • Chromatin remodeling
    • • Topological domains
  4. Chapter 4: DNA Replication

    • • The replication fork
    • • DNA polymerases
    • • Initiation and termination
  5. Chapter 5: DNA Damage and Repair

    • • Mutagens and DNA lesions
    • • Excision repair pathways
    • • Double-strand break repair
  6. Chapter 6: Homologous Recombination and Transposition

    • • Meiotic recombination
    • • Transposable elements
    • • Site-specific recombination
  7. Chapter 7: Transcription in Bacteria

    • • RNA polymerase structure
    • • Promoter recognition
    • • Transcription termination
  8. Chapter 8: Transcription in Eukaryotes

    • • Pol I, II, and III transcription
    • • General transcription factors
    • • Enhancers and promoters
  9. Chapter 9: RNA Processing and Post-Transcriptional Regulation

    • • Splicing mechanisms
    • • Capping and polyadenylation
    • • RNA decay and stability
  10. Chapter 10: Translation and the Genetic Code

    • • Ribosome structure
    • • tRNA charging
    • • Translation initiation, elongation, and termination
  11. Chapter 11: Regulation of Gene Expression

    • • Operons and bacterial regulation
    • • Eukaryotic transcriptional activators
    • • Epigenetic inheritance
  12. Chapter 12: Molecular Biology Techniques and Experimental Approaches

    • • Recombinant DNA technology
    • • PCR and sequencing
    • • Gene editing and CRISPR-Cas9

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  • Molecular Biology - Paperback - Nancy Craig, Rachel Green, Carol ...
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