Plasmids
Biology and Impact in Biotechnology and Discovery
by Marcelo E. Tolmasky, Juan C. Alonso
1st Edition
Publisher: ASM Press
Book Details
| Print ISBN | 9781555818975 |
| eText ISBN | 9781683673392 |
| Publisher | ASM Press |
| Publishing Year | 2015 |
| Edition | 1st Edition |
| Language | English |
| Pages | 718 |
Plasmids: Biology and Impact in Biotechnology and Discovery, 1st Edition, explores the molecular mechanisms of plasmid biology alongside practical uses in biotechnology and pharmacology. The text examines fundamental functional pathways, maintenance systems, and genetic applications.
Core areas of coverage include replication mechanisms, partition systems, and horizontal transfer across diverse microbial hosts. The volume also addresses ecological dynamics, examining plasmid-mediated antimicrobial resistance and virulence determinants such as those demonstrated in the Klebsiella pneumoniae model.
Designed as both a reference and an instructional resource, this textbook serves researchers across biological disciplines as well as upper-level undergraduate and graduate courses in biotechnology and molecular biology.
Table of Contents
Chapter 1: Historical Events That Spawned the Field of Plasmid Biology
Chapter 2: Iteron Plasmids
Chapter 3: Mechanisms of Theta Plasmid Replication
Chapter 4: Plasmid Rolling-Circle Replication
Chapter 5: Replication and Maintenance of Linear Phage-Plasmid N15
Chapter 6: Plasmid Replication Control by Antisense RNAs
Chapter 7: Topological Behavior of Plasmid DNA
Chapter 8: Plasmid Partition Mechanisms
Chapter 9: Resolution of Multimeric Forms of Circular Plasmids and Chromosomes
Chapter 10: Conditional Activation of Toxin-Antitoxin Systems: Postsegregational Killing and Beyond
Chapter 11: The Interplay between Different Stability Systems Contributes to Faithful Segregation: Streptococcus pyogenes pSM19035 as a Model
Chapter 12: The CRISPR-Cas Immune System and Genetic Transfers: Reaching an Equilibrium
Chapter 13: Plasmid Diversity and Adaptation Analyzed by Massive Sequencing of Escherichia coli Plasmids
Chapter 14: Conjugation in Gram-Positive Bacteria
Chapter 15: Mobilizable Rolling-Circle Replicating Plasmids from Gram-Positive Bacteria: A Low-Cost Conjugative Transfer
Chapter 16: The Plasmid Mobilome of the Model Plant Symbiont Sinorhizobium meliloti: Coming up with New Questions and Answers
Chapter 17: The Agrobacterium Ti Plasmids
Chapter 18: The Influence of Biofilms in the Biology of Plasmids
Chapter 19: The Partitioning and Copy Number Control Systems of the Selfish Yeast Plasmid: An Optimized Molecular Design for Stable Persistence in Host Cells
Chapter 20: Plasmids from Euryarchaeota
Chapter 21: The Plasmidome of Firmicutes: Impact on the Emergence and the Spread of Resistance to Antimicrobials
Chapter 22: Plasmid-Mediated Antimicrobial Resistance in Staphylococci and Other Firmicutes
Chapter 23: Plasmid Detection, Characterization, and Ecology
Chapter 24: Plasmid-Mediated Antibiotic Resistance and Virulence in Gram-Negatives: The Klebsiella pneumoniae Paradigm
Chapter 25: Plasmid-Mediated Quinolone Resistance
Chapter 26: Plasmid-Mediated Tolerance Toward Environmental Pollutants
Chapter 27: Virulence Plasmids of Spore-Forming Bacteria
Chapter 28: Virulence Plasmids of Nonsporulating Gram-Positive Pathogens
Chapter 29: Plasmid-Encoded Iron Uptake Systems
Chapter 30: DNA Assembly Tools and Strategies for the Generation of Plasmids
Chapter 31: Plasmids as Tools for Containment
Chapter 32: Mining Environmental Plasmids for Synthetic Biology Parts and Devices
Chapter 33: Using Plasmids as DNA Vaccines for Infectious Diseases
Chapter 34: Plasmid Biopharmaceuticals
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