Role of Biomarkers in Cancer Diagnosis and Therapeutics

Name: Role of Biomarkers in Cancer Diagnosis and Therapeutics
Price: 200 USD
Availability: InStock
ISBN: 9780443440410

by Sushama Talegaonkar, Lalit Kumar, Dalapathi Gugulothu

1st Edition

Publisher: Academic Press

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Oncology

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Book Details

Print ISBN	9780443440410
eText ISBN	9780443440427
Publisher	Academic Press
Publishing Year	2026
Edition	1st Edition
Language	English
Pages	684

The 1st Edition of Role of Biomarkers in Cancer Diagnosis and Therapeutics offers a structured reference detailing the evaluation and clinical utility of biological indicators in cancer detection, diagnosis, patient monitoring, and treatment selection. Formulated for clinicians as well as researchers operating across molecular biology, biochemistry, and oncology, the text addresses both diagnostic screening and targeted interventions.

The core material synthesizes diagnostic profiles across distinct operational levels. It addresses established clinical markers including Prostate-Specific Antigen (PSA) and Carcinoembryonic Antigen (CEA) before moving into broader analytical models such as epigenetic markers and microbiome indicators. Additional sections analyze fundamental oncological pathways, focusing on cell cycle checkpoints and topoisomerase-induced DNA damage.

Looking toward advanced clinical practice, the volume outlines future developments in personalized cancer care, incorporating multi-omics strategies alongside artificial intelligence integration. This systematic coverage provides active researchers and medical specialists with grounded insights into current diagnostic platforms and targeted therapeutic frameworks.

Chapter 1: Prostate-Specific Antigen (PSA)
Chapter 2: Carcinoembryonic Antigen (CEA)
Chapter 3: Tissue Polypeptide-Specific Antigen (TPS) CA72-4
Chapter 4: Carbohydrate Antigen 19-9 (CA19-9)
Chapter 5: Carbohydrate Antigen 125 (CA-125)
Chapter 6: Carbohydrate Antigen 72-4 (CA72-4)
Chapter 7: Aminopeptidase N
Chapter 8: Alkaline Phosphatase
Chapter 9: CD26/Dipeptidyl Peptidase (DPP)4
Chapter 10: Genetic Biomarkers in Cancer
Chapter 11: Immunology Biomarkers in Cancer
Chapter 12: Microbiome Biomarkers in Cancer
Chapter 13: Glycobiology Biomarkers in Cancer
Chapter 14: Epigenetic Biomarkers in Cancer
Chapter 15: Introduction to Metabolic Targets and Autophagy
Chapter 16: Glucose Metabolism – Hexokinase-2 (HK2), Lactate Dehydrogenase A (LDHA), Pyruvate Kinase M2 Isoform (PKM2), Pyruvate Dehydrogenase (PDK), Glucose Transporter, Enolase 1 (ENO1), and Monocarboxylate Transporter (MCT1)
Chapter 17: Nucleic Acid Metabolism – Folate Cycle, Nucleotide Incorporation (DNA Polymerase/Ribonucleotide Reductase (RNR)), Deoxynucleotide Synthesis (RNR), and Thymidine Synthesis (TYMS)
Chapter 18: Amino Acid Metabolism – Arginine and Asparagine, Serine/Threonine Protein Kinase (Glycogen Synthase Kinase-3 (GSK-3))
Chapter 19: Glucose and Amino Acid Metabolism - Isocitrate Dehydrogenase-1 (IDH-1)
Chapter 20: Glucose, Nucleic Acid, Fatty Acid, and Amino Acid Metabolism – Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH)
Chapter 21: Targeting DNA Repair Pathways – O-6-Methylguanine-DNA Methyltransferase (MGMT), Base Excision Repair, Double Strand Breaks Repair, and mtDNA Repair
Chapter 22: Cell Cycle Inhibition – Cyclin-Dependent Kinases (CDKs), and G1 Checkpoint
Chapter 23: Topoisomerase-Induced DNA Damage and Therapeutic Potential
Chapter 24: Polo-like Kinase 4 (PLK4) Inhibitors in Cancer Therapy
Chapter 25: Synthetic Lethality by Poly (ADP-Ribose) Polymerase Inhibitors
Chapter 26: Innovative Therapeutic Approaches