Seldin and Giebisch's The Kidney
Physiology and Pathophysiology
by Robert J. Alpern, Michael J. Caplan, Orson W. Moe, Susan E. Quaggin
6th Edition
Publisher: Academic Press
Book Details
| Print ISBN | 9780128153895 |
| eText ISBN | 9780128153901 |
| Publisher | Academic Press |
| Publishing Year | 2026 |
| Edition | 6th Edition |
| Language | English |
| Pages | 2956 |
Seldin and Giebisch's The Kidney, 6th Edition, is an extensive reference work designed to detail normal renal physiology and the pathophysiology of kidney diseases. Academic Press released this 2026 publication under the editorial direction of Robert J. Alpern, Michael J. Caplan, Orson W. Moe, and Susan E. Quaggin.
The content integrates foundational membrane transport and cellular signaling principles with complex clinical conditions. Key thematic areas include fluid and electrolyte disorders, acid-base balance, genetic disorders, glomerular diseases, and the primary cellular and molecular mechanisms of renal disease.
Bound as a two-volume print set of 2,956 pages, the text organizes complex physiological and clinical material into a unified reference framework. This structure allows readers to locate detailed biological concepts and clinical disease mechanisms across both volumes.
Table of Contents
Chapter 1: Epithelial cell structure and polarity
Chapter 2: Mechanisms of ion and water transport across cell membranes and epithelia
Chapter 3: Renal ion-translocating ATPases
Chapter 4: Cell volume control
Chapter 5: Solute transport, energy consumption and production in the kidney
Chapter 6: Electrophysiological analysis of transepithelial transport
Chapter 7: Renal ion channels, electrophysiology of transport and channelopathies
Chapter 8: Microvascular permeability and the exchange of water and solutes across microvascular walls
Chapter 9: Renal cilia structure, function, and physiology
Chapter 10: Intercellular junctions and cell–matrix interactions
Chapter 11: Principles of cell signaling
Chapter 12: Scaffolding proteins in transport regulation
Chapter 13: The renin–angiotensin system
Chapter 14: Neural control of renal function
Chapter 15: Eicosanoids and renal function
Chapter 16: Extracellular nucleotides, metabolites, and renal function
Chapter 17: Structural organization of the mammalian kidney
Chapter 18: Biophysical basis of glomerular filtration
Chapter 19: Glomerular cell biology
Chapter 20: Function of the juxtaglomerular apparatus: control of glomerular hemodynamics and renin secretion
Chapter 21: Vasculature of the kidney cortex and medulla
Chapter 22: The development of the kidney
Chapter 23: Molecular and cellular mechanisms of glomerular capillary development
Chapter 24: Epithelial Na + channels
Chapter 25: Anion channels
Chapter 26: Physiology and pathophysiology of the NaCl cotransporters in the kidney
Chapter 27: Balance and the pathophysiology of acid–base, fluid, and electrolyte disorders
Chapter 28: Sodium and chloride transport in the proximal tubule
Chapter 29: Mineralocorticoid action in the aldosterone-sensitive distal nephron
Chapter 30: Genetic disorders of renal salt homeostasis and blood pressure
Chapter 31: Pathophysiology of sodium retention and wastage
Chapter 32: Physiology and pathophysiology of hypertension
Chapter 33: Aquaporin water channels in mammalian kidney
Chapter 34: Thirst and vasopressin
Chapter 35: The urine-concentrating mechanism and urea transporters
Chapter 36: Hyponatremia
Chapter 37: Hypernatremic states
Chapter 38: The function and regulation of renal K + channels
Chapter 39: Extrarenal potassium metabolism
Chapter 40: Regulation of K⁺ excretion
Chapter 41: Physiopathology of potassium deficiency
Chapter 42: Clinical disorders of hyperkalemia
Chapter 43: Intracellular pH homeostasis
Chapter 44: SLC4 sodium-coupled bicarbonate and carbonate transporters
Chapter 45: Anion exchangers of the SLC4 gene family
Chapter 46: Cellular mechanisms of renal tubular acidification
Chapter 47: Renal ammonium ion production and transport
Chapter 48: Clinical syndromes of metabolic alkalosis
Chapter 49: Clinical syndromes of metabolic acidosis
Chapter 50: Respiratory acid–base disorders
Chapter 51: Mechanisms and disorders of magnesium metabolism
Chapter 52: Calcium channels
Chapter 53: The calcium-sensing receptor
Chapter 54: Renal calcium metabolism
Chapter 55: Kidney stones
Chapter 56: Proximal tubular handling of phosphate
Chapter 57: Clinical disturbances of phosphate homeostasis
Chapter 58: Glucose reabsorption in the kidney
Chapter 59: Kidney transport of amino acids and oligopeptides and aminoacidurias
Chapter 60: Renal filtration, transport, and metabolism of albumin and albuminuria
Chapter 61: Physiologic principles in the clinical evaluation of electrolyte, water, and acid–base disorders
Chapter 62: Acute kidney injury biomarkers
Chapter 63: Pathophysiology of acute kidney injury
Chapter 64: Ischemic renal disease
Chapter 65: Pathophysiology and pathogenesis of diabetic kidney disease
Chapter 66: Autosomal dominant polycystic kidney disease
Chapter 67: Renal physiology and disease in pregnancy
Chapter 68: Glomerular disorders
Chapter 69: Immunologic mechanisms of vasculitis
Chapter 70: Genetic abnormalities in glomerular function
Chapter 71: Mechanisms of drug nephrotoxicity
Chapter 72: Role of proteinuria in the progression of renal disease
Chapter 73: Oxidative stress and signaling in renal physiology and kidney diseases
Chapter 74: Pathogenesis and management of disordered mineral metabolism in patients with chronic kidney disease
Chapter 75: Individualizing the dialysate to address electrolyte disturbances in the dialysis patient
Chapter 76: Mechanisms of allograft rejection
Chapter 77: Homeostasis of solute and water by the transplanted kidney
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▶Research Sources (13)
- Seldin and Giebisch's The Kidney - Elsevier Shop
- eBook Details
- Seldin and Giebisch's The Kidney: Physiology and ...
- eBook Details
- eBook Details | Alabama Aviation College Bookstore
- All books by Orson W. Moe author
- Seldin and Giebisch's The Kidney : Robert J. Alpern (editor)
- Seldin and Giebisch's The Kidney, eBook by Robert J. Alpern
- Seldin and Giebisch's The Kidney
- SELDIN and GIEBISCH's The Kidney. Physiology and ... - AXON
- Seldin and Giebisch's The Kidney: Physiology ...
- Seldin and Giebisch's The Kidney by Caplan
- Seldin and Giebisch's Kidney Physiology | PDF