Solid-State Materials in Pharmaceutical Chemistry

Solid-State Materials in Pharmaceutical Chemistry, 2nd Edition offers instruction on controlling physical and chemical attributes of drug components to support the development of safe, effective medicines. This textbook presents analytical and material principles for evaluating physical state stability and therapeutic performance across diverse chemical entities.

The content spans small molecule compounds, peptides, proteins, and nucleic acids across amorphous states, mesophases, polymorphs, solvates, pharmaceutical salts, co-crystals, nanoparticles, and solid dispersions. Analytical methods detailed for solid form identification include X-Ray powder diffraction, thermal characterization, optical microscopy, solid-state NMR, spectroscopy, moisture sorption, particle sizing, mechanical testing, solubility measurements, and dissolution assays.

This updated second edition incorporates dedicated chapters covering the physical and chemical properties of RNA therapeutics along with final stage drug substance manufacturing and control. The material supports advanced undergraduate and graduate students in pharmaceutical chemistry, drug delivery, pharmaceutics, biopharmaceutics, material science, and crystal engineering.