The Human Mitochondrial Genome
From Basic Biology to Disease
by Giuseppe Gasparre, Anna Maria Porcelli
1st Edition
Publisher: Academic Press
Book Details
| Print ISBN | 9780128196564 |
| eText ISBN | 9780128226421 |
| Publisher | Academic Press |
| Publishing Year | 2020 |
| Edition | 1st Edition |
| Language | English |
| Pages | 596 |
The Human Mitochondrial Genome: From Basic Biology to Disease, 1st Edition, connects basic research in mitochondrial genetics to translational medicine. The volume provides an overview of mitochondrial genome function across normal cellular processes and human disease contexts.
Core biological coverage examines the maintenance, repair, segregation, and heredity of human mitochondrial DNA. The book addresses diverse pathologies, including cancer, neurodegenerative conditions, age-related diseases, and disorders characterized by mitochondrial DNA depletion, deletion, and point mutations.
The work outlines experimental research protocols and perspectives intended for early-career scientists. It serves active researchers and clinician-scientists working across biochemistry, molecular biology, cell biology, oncology, neurology, neuroscience, and pharmacology.
Table of Contents
Chapter 1: MtDNA replication, maintenance and nucleoid organization
Chapter 2: Human mitochondrial transcription and translation
Chapter 3: Epigenetic features of mitochondrial DNA
Chapter 4: Heredity and Segregation of mtDNA
Chapter 5: Haplogroups and the history of human evolution through mtDNA
Chapter 6: Human Nuclear mitochondrial Sequences (NumtS)
Chapter 7: MtDNA exploitation in forensics
Chapter 8: Human mitochondrial DNA repair
Chapter 9: Mechanisms of onset and accumulation of mtDNA mutations
Chapter 10: Mitochondrial DNA mutations and ageing
Chapter 11: Methods for the identification of mitochondrial DNA variants
Chapter 12: Bioinformatics resources, databases, and tools for human mtDNA
Chapter 13: Methods and models for functional studies on mtDNA mutations
Chapter 14: Mitochondrial DNA point mutation diseases
Chapter 15: Nuclear genetic disorders of mitochondrial DNA gene expression
Chapter 16: mtDNA maintenance: disease and therapy
Chapter 17: MtDNA mutations in cancer
Chapter 18: MitoTALENs for mtDNA editing
Chapter 19: Mitochondrially-Targeted Zinc Finger Nucleases
Chapter 20: Mitochondrial movement between mammalian cells: an emerging physiological phenomenon
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