The Immune System
by Peter Parham
5th Edition
Publisher: W. W. Norton & Company
Book Details
| Print ISBN | 9780393533354 |
| eText ISBN | 9780393533309 |
| Publisher | W. W. Norton & Company |
| Publishing Year | 2021 |
| Edition | 5th Edition |
| Language | English |
| Pages | 624 |
Understanding the human body's defense mechanisms has never been more critical to global public health and clinical medical practice. The Immune System 5th Edition offers a beautifully clear, comprehensive, and highly accessible entry point into this complex biological landscape, translating intricate cellular interactions into digestible concepts. As medical science advances at an unprecedented pace, having a reliable, human-centric guide is absolutely essential for students who need to grasp how our bodies combat diverse pathogens. This textbook stands out in the field by focusing specifically on human immunology, ensuring that every biological pathway and molecular mechanism discussed has direct, tangible relevance to clinical outcomes and patient care. By bridging the gap between basic research and clinical application, it empowers the next generation of healthcare professionals.
Author Peter Parham employs a highly structured, logical narrative that guides readers through the diverse components of the host immune response, from the immediate actions of innate defenses to the highly specific, long-lasting protections of adaptive immunity. The text thoroughly explores the development of B and T lymphocytes, the structural nuances of antibodies, and the critical processes of antigen recognition. By framing the entire immune system as an evolutionary shield against a hostile microbial environment, the author provides a cohesive, unified perspective that seamlessly connects basic biological research with real-world medical challenges. This approach helps students appreciate the evolutionary pressures that have shaped our biological defenses.
Designed primarily for undergraduate biology majors, graduate students, and medical school students, this textbook utilizes vibrant illustrations, clear schematic art, and detailed micrographs to reinforce complex physiological processes. This edition integrates numerous clinical examples, including graft rejection, autoimmune disorders, and hypersensitivity reactions, to demonstrate what happens when these defenses fail. Students looking to master these challenging concepts can utilize The Immune System 5th Edition PDF to access these rich visual resources, detailed case connections, and comprehensive chapter summaries on any digital device. Ultimately, The Immune System 5th Edition remains the premier academic resource for building a functional, lasting foundation in modern immunology.
Table of Contents
Chapter 1: Elements of the Immune System and Their Roles in Defense
- • Pathogens, immunogens, and vaccines
- • Innate versus adaptive immunity
- • Cells of the immune system
- • Lymphoid tissues and organs
Chapter 2: Innate Immunity: The Immediate Response to Infection
- • Physical barriers and chemical defenses
- • The complement system
- • Coagulation and protease inhibitors
- • Defensins and other antimicrobial peptides
Chapter 3: Innate Immunity: The Induced Response to Infection
- • Pattern recognition receptors
- • Toll-like receptors and signaling
- • Cytokines and chemokines
- • Inflammatory response and phagocytosis
Chapter 4: Antibody Structure and the Generation of B-Cell Diversity
- • Immunoglobulin structure
- • Antigen-binding sites
- • V(D)J recombination
- • Somatic hypermutation and isotype switching
Chapter 5: Antigen Recognition by T Lymphocytes
- • T-cell receptor structure
- • MHC class I and II molecules
- • Antigen processing and presentation
- • MHC restriction and polymorphism
Chapter 6: The Development of B Lymphocytes
- • B-cell development in the bone marrow
- • Gene rearrangement and checkpoint selection
- • Receptor editing
- • Survival and maturation in secondary lymphoid tissues
Chapter 7: The Development of T Lymphocytes
- • T-cell development in the thymus
- • Positive selection for MHC restriction
- • Negative selection for self-tolerance
- • Lineage commitment
Chapter 8: T Cell-Mediated Immunity
- • Activation of naive T cells by dendritic cells
- • Properties and functions of effector T cells
- • Cytotoxic T cells
- • Helper T cell subsets (Th1, Th2, Th17, Treg)
Chapter 9: Immunity Mediated by B Cells and Antibodies
- • B-cell activation and germinal center reaction
- • Plasma cell differentiation
- • Effector functions of antibodies
- • Fc receptors
Chapter 10: Preventing Infection at Mucosal Surfaces
- • Organization of the mucosal immune system
- • Mucins and intraepithelial lymphocytes
- • Secretory IgA
- • Regulation of mucosal immune responses
Chapter 11: Immunological Memory and Vaccination
- • Generation and maintenance of memory cells
- • Primary versus secondary immune responses
- • Active versus passive immunization
- • Vaccine design and adjuvants
Chapter 12: Coevolution of Innate and Adaptive Immunity
- • NK cell receptors
- • Innate lymphoid cells
- • Interaction with dendritic cells
- • MHC class I recognition
Chapter 13: Failures of the Body's Defenses
- • Primary immunodeficiency diseases
- • Secondary immunodeficiencies and HIV/AIDS
- • Evasion of the immune system by pathogens
- • Superantigens
Chapter 14: Allergy and the Immune Response to Parasites
- • IgE-mediated hypersensitivity
- • Mast cells, basophils, and eosinophils
- • Allergic rhinitis, asthma, and anaphylaxis
- • Type II, III, and IV hypersensitivities
Chapter 15: Transplantation of Tissues and Organs
- • Alloantigens and alloreactivity
- • Graft-versus-host disease
- • Blood transfusion and HLA typing
- • Immunosuppressive drugs
Chapter 16: Disruption of Healthy Tissue by the Adaptive Immune Response
- • Autoimmune diseases
- • Loss of self-tolerance
- • Genetic and environmental factors
- • Celiac disease and chronic inflammation
Chapter 17: Cancer, Immunity, and Immunotherapy
- • Tumor antigens
- • Immune surveillance and escape
- • Monoclonal antibodies in cancer therapy
- • Checkpoint inhibitors and CAR-T cells
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