Adenoviral Vectors for Gene Therapy
by David T. Curiel, Alan L. Parker
3rd Edition
Publisher: Academic Press
Book Details
| Print ISBN | 9780323898218 |
| eText ISBN | 9780323958141 |
| Publisher | Academic Press |
| Publishing Year | 2025 |
| Edition | 3rd Edition |
| Language | English |
| Pages | 906 |
Adenoviral Vectors for Gene Therapy, 3rd Edition, edited by David T. Curiel and Alan L. Parker, is a reference book dedicated to adenoviral vector engineering and therapeutic gene transfer. Published by Academic Press in 2025, the text outlines fundamental viral properties and technical procedures for vector production, supporting scientific research in targeted gene delivery.
The material opens with the basic biology of adenoviruses to explain primary viral functions and assembly principles. It then advances through practical protocols for vector construction, propagation, and purification. The text further examines cutting-edge vectorology alongside preclinical animal disease models, providing a logical progression of topics that connects underlying viral mechanics to experimental animal testing.
This updated release highlights specialized subject areas, including nonhuman primate adenoviruses and oncolytic adenoviruses for antitumor immunization. The content serves as a resource for researchers in virology, researchers in genetics and gene therapy, therapeutics research professionals, and translational physician-scientists managing gene transfer projects.
Table of Contents
Chapter 1: Structural Biology of Adenovirus
Chapter 2: Biology of Adenovirus Cell Entry: Receptors, Pathways, Mechanisms
Chapter 3: Adenovirus Replication
Chapter 4: Adenoviral Vector Construction I: Mammalian Systems
Chapter 5: Adenoviral Vector Construction II: Bacterial Systems
Chapter 6: Adenoviral Vector Packing Cell Lines
Chapter 7: Purification of Adenovirus
Chapter 8: Innate Immune Response to Adenovirus
Chapter 9: Antibodies to Adenovirus
Chapter 10: Methods to Mitigate Immune Response
Chapter 11: Xenogenic Adenoviral Vectors as Vaccines
Chapter 12: Adenoviral Vector Targeting
Chapter 13: Helper-Dependent Adenovirus
Chapter 14: Hybrid Adenoviral Vectors
Chapter 15: Canine Adenovirus
Chapter 16: Oncolytic Adenovirus
Chapter 17: Imaging Analysis
Chapter 18: Adenoviral Vaccines - Cancer
Chapter 19: Adenoviral Vaccines - Infectious Disease
Chapter 20: Adenoviral Vaccines - COVID 19
Chapter 21: Adenoviral Vectored Veterinary Vaccines
Chapter 22: Utility of Adenoviral Vectors in Animal Models - CV Disease
Chapter 23: Utility of Adenoviral Vectors in Animal Models - Pulmonary Disease
Chapter 24: Utility of Adenoviral Vectors in Animal Models - Genetic Disease
Chapter 25: Adenoviral Vectors for Gene Editing
Chapter 26: Manufacturing and Upscaling
Chapter 27: Regulation of Adenoviral Vector-Based Therapies: An FDA Perspective
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