Applied Physical Pharmacy, Third Edition
by Mansoor Amiji, Thomas J. Cook, W. Cary Mobley
3rd Edition
Publisher: McGraw-Hill Education / Medical
Book Details
| Print ISBN | 9781260452211 |
| eText ISBN | 9781260452228 |
| Publisher | McGraw-Hill Education / Medical |
| Publishing Year | 2020 |
| Edition | 3rd Edition |
| Language | English |
| Pages | 288 |
Applied Physical Pharmacy, Third Edition, is a textbook that introduces physical pharmacy through an applied, practice-oriented perspective. The text explores how drugs are transformed into usable products administered to patients to reach pharmacological targets before exiting the body.
Core chapters examine the LADME framework of drug liberation, absorption, distribution, metabolism, and excretion. The volume then addresses the physical and chemical properties governing drug behavior, including states of matter, solutions, interfacial phenomena, dispersed systems, and rheology.
Designed for pharmacy students, this 2020 edition features learning objectives, key points, practice problems, and an appendix covering foundational mathematics. The 2020 release also added more clinical questions and updated tables of commercial products and excipients.
Table of Contents
Chapter 1: Introduction to Biopharmaceutics
- • Introduction
- • Drug Disposition—The Fate of the Drug After Administration
- • Ladme
- • Conclusion
- • Key Point
- • Clinical Questions
Chapter 2: States of Matter Related to Pharmaceutical Formulations
- • Introduction
- • Intermolecular Forces
- • States of Matter
- • Stability of Solids
- • Acknowledgment
- • Problems
- • Answers
- • Key Points
- • Clinical Questions
- • Appendix
Chapter 3: Physical Properties of Solutions
- • General Considerations
- • Concentration Expressions
- • Classification of Aqueous Solution Systems
- • Physical Properties of Solutions
- • Physiologic Applications of Colligative Properties
- • Isotonic Solutions
- • Sodium Chloride Equivalent Values (E)
- • Problems
- • Answers
- • Key Points
- • Clinical Questions
- • Appendix
Chapter 4: Ionic Equilibria and Buffers
- • Electrolytes Versus Nonelectrolytes
- • Importance of Ionization in Pharmacy
- • Acids and Bases
- • Ionization of Water
- • Ionization of Electrolytes
- • Ionization of Salts
- • Buffers
- • Ionization of Amphoteric Electrolytes
- • Ionization of Polyprotic Acids
- • Activity and Activity Coefficient
- • Acid–Base Titration and Titration Curve
- • Problems
- • Answers
- • Key Points
- • Clinical Questions
- • Appendix: Suggested Readings
Chapter 5: Solubility, Dissolution, and Partitioning
- • Solubility
- • Dissolution
- • Dissolution of Particles
- • Factors Affecting Drug Dissolution
- • Partitioning
- • Solubility Problems
- • Answers
- • Dissolution Problems
- • Partitioning Problems
- • Key Points
- • Clinical Questions
- • Appendix
Chapter 6: Mass Transport
- • Introduction
- • Transport Systems
- • Diffusion Through a Membrane
- • Significance of Diffusion
- • Significance of Osmosis
- • Problems
- • Answers
- • Key Points
- • Clinical Questions
Chapter 7: Complexation and Protein Binding
- • Introduction
- • Types of Complexes
- • Metal–Ion Coordinate Complexes
- • Cyclodextrin Complexes
- • Ion-Exchange Resins
- • Protein–Ligand Interactions
- • Plasma Protein Binding
- • Problems
- • Answers
- • Key Points
- • Clinical Questions
- • Appendix
Chapter 8: Dispersed Systems
- • Dispersed Systems Classified by Their Phases
- • Dispersed Systems Classified by Their Particle Size
- • Physical Stability of Dispersed Systems
- • Summary
- • Problems
- • Answers
- • Key Points
- • Clinical Questions
- • Suggested Readings
Chapter 9: Interfacial Phenomena
- • Surface Tension
- • Electrical Double Layer
- • Adsorption
- • Problems
- • Answers
- • Key Points
- • Clinical Questions
- • Appendix
Chapter 10: Rheology
- • Introduction
- • Newtonian Flow
- • Viscosity of Newtonian Fluids
- • Effect of Temperature on Viscosity
- • Non-Newtonian Flow
- • Thixotropy
- • Viscoelasticity
- • Significance of Rheology
- • Viscosity Modifiers
- • Problems
- • Answers
- • Key Points
- • Clinical Questions
- • Appendix
Chapter 11: Chemical Kinetics of Pharmaceuticals
- • Common Drug Degradation Reactions
- • Order of Reaction
- • Determination of the Order of a Reaction
- • Stability and Shelf-Life of Drugs
- • Enzyme Catalysis Reactions
- • Pharmacokinetics: An Extension of Reaction Kinetics
- • Problems
- • Answers
- • Clinical Questions
- • Suggested Readings
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