Autophagy in Health and Disease
by Beverly A. Rothermel
2nd Edition
Publisher: Academic Press
Book Details
| Print ISBN | 9780128220030 |
| eText ISBN | 9780128220047 |
| Publisher | Academic Press |
| Publishing Year | 2021 |
| Edition | 2nd Edition |
| Language | English |
| Pages | 454 |
*Autophagy in Health and Disease*, 2nd Edition, is a book that examines the cellular process of autophagy and its impact on human physiology and pathology. Edited by Beverly A. Rothermel, the work surveys foundational autophagic machinery and connects cellular degradation mechanisms to complex disease states.
The volume explores developmental roles such as embryogenesis and paligenosis alongside major organ systems. It also considers how autophagic pathways influence metabolic control, cardiovascular function, and neurodegenerative disorders.
Contributed by researchers from 15 countries, the text highlights unresolved questions across the field. It provides support for researchers, graduate students, and professionals working in biochemistry, cell biology, medicine, and biomedical sciences.
Table of Contents
Chapter 1: Introduction
Chapter 2: Mechanisms of autophagy: the machinery of macroautophagy and points of control
Chapter 3: Regulation of autophagy - transcriptional, posttranscriptional, translational, and posttranslational mechanisms
Chapter 4: Selectivity and trafficking of autophagic cargoes
Chapter 5: The role of lysosomes in autophagy
Chapter 6: Methods for measuring autophagy
Chapter 7: Effects of physiologic inputs on autophagy
Chapter 8: Autophagy in germ cells, stem cells, and induced pluripotent stem cells
Chapter 9: Role of autophagy in embryogenesis
Chapter 10: Autophagy in hematopoiesis and leukemogenesis
Chapter 11: Autophagy in cell plasticity with particular focus on paligenosis
Chapter 12: Autophagy in the liver
Chapter 13: Autophagy in adipose tissue
Chapter 14: Autophagy in the pancreas
Chapter 15: Skeletal muscle
Chapter 16: Autophagy in the cardiovascular system
Chapter 17: Lungs
Chapter 18: Autophagy in the vasculature
Chapter 19: Altered autophagy on the path to Parkinson's disease
Chapter 20: Autophagic processes in early- and late-onset Alzheimer's disease
Chapter 21: Autophagy as an integral immune system component
Chapter 22: Autophagy in the gastrointestinal system and cross talk with microbiota
Chapter 23: Role of autophagy in building and maintaining the skeletal system
Chapter 24: Autophagy on the road to longevity and aging
Chapter 25: Autophagy in cancer: friend or foe?
Chapter 26: Mammalian microautophagy: mechanism and roles in disease
Chapter 27: Chaperone-mediated autophagy - mechanisms and disease role
Chapter 28: Targeting autophagy: lifestyle and pharmacological approaches
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