Bioprocess Engineering Principles

Name: Bioprocess Engineering Principles
Price: 95.99 USD
Availability: InStock
ISBN: 9780128221914

by Ross Carlson, Kate Morrissey, Pauline M. Doran

3rd Edition

Publisher: Academic Press

(0 reviews)

Biotechnology

Compare Prices

VitalSourceLifetime Access$95.99 AmazonKindle$76.79 Best PriceeTextShelfPDF$38.00

Book Details

Print ISBN	9780128221914
eText ISBN	9780128221938
Publisher	Academic Press
Publishing Year	2024
Edition	3rd Edition
Language	English
Pages	693

Bioprocess Engineering Principles, 3rd Edition provides an introduction to bioprocess engineering for students with a limited engineering background. The textbook presents process analysis from an engineering perspective to establish fundamental bioprocessing concepts.

The thematic scope provides in-depth treatment of fluid physical behavior, covering fluid flow, turbulence, fluid mixing, and impeller design. Technical topics extend to enzyme kinetics and unit operations within downstream processing. Furthermore, the material demonstrates how these analytical concepts relate to broader application areas, including drug development, tissue engineering, microbial fermentation, recombinant protein production, bioplastics synthesis, biofuels manufacturing, and environmental bioremediation.

To assist quantitative skill development, the volume includes more than 350 practice problems that apply core principles across diverse biological sectors. This content is structured for senior undergraduate students majoring in chemical engineering, biomedical engineering, or applied biology who are enrolled in final-year options in bioprocessing or biotechnology.

Chapter 1: Purpose of this edition (Scope of textbook)
- • Relevance
- • Teaching Bioprocess Engineering
- • Student and Instructor Resources
Chapter 2: Bioprocess Development: An Interdisciplinary Challenge
- • Steps in Bioprocess development
- • Key Processes/Examples
Chapter 3: Microbiology and Biochemistry
- • Cells and Organisms
- • Nomenclature
- • Prokaryotes
- • Eukaryotes
- • Viruses
- • Cellular Composition and Basic Metabolism
- • Biomass Macromolecular Components
- • Basic Metabolism
- • Growth Media
- • Chapter Summary
Chapter 4: Material Balances
- • Thermodynamic Principles
- • Law of Conservation of Mass
- • Material Balance Calculations
- • Unsteady-State Material Balance Equations
- • Stoichiometry of Cell Growth and Product Formation
- • Worked Examples
Chapter 5: Energy Balances
- • Basic Energy Concepts
- • General Energy Balance Equations
- • Energy Balance for Nonreactive Processes
- • Energy Balance Due to Reaction
- • Unsteady-State Energy Balance Equations
- • Enthalpy Calculations
- • Enthalpy Change for Nonreactive Processes
- • Enthalpy Change Due to Reaction
- • Heat of Reaction for Process with Biomass Production
- • Cell Culture Energy Balance
- • Worked Examples
- • Chapter Summary
Chapter 6: Enzyme and Cell Growth Kinetics
- • Introduction to Enzymes
- • Enzyme Kinetics
- • General Reaction Kinetics
- • Basic Reaction Theory
- • Michaelis-Menten
- • Inhibition models
- • pH and Temperature Effects
- • Worked Examples
- • Cell Growth
- • Cell Culture Yields
- • Cell Growth Kinetics
- • Substrate Uptake Kinetics
- • Production Kinetics
- • Culture Condition Effects
- • Chapter Summary
Chapter 7: Bioreactors
- • Reactor Engineering
- • Homogeneous Reactions
- • Heterogeneous Reactions
- • Monitoring and Control of Bioreactors
- • Practical Considerations for Bioreactor Design
- • Aseptic Operation
- • Inoculation and Sampling
- • Impeller, Baffle, and Sparger Design
- • Evaporation Control
- • Bioreactor Configurations
- • Ideal Bioreactor Operation
- • Sterilisation
- • Sterilisation of Liquids
- • Sterilisation of Air
- • Worked Examples
- • Chapter Summary
Chapter 8: Mixing
- • Functions of Mixing
- • Mixing Equipment
- • Power Inputs and Pumping Capacity
- • Mechanisms of Mixing
- • Factors Affecting Mixing Effectiveness, Scale-up, and Improving Mixing Systems
- • Worked Examples
- • Chapter Summary
Chapter 9: Bioreactor Mass Transfer
- • Molecular Diffusion
- • Role of Diffusion in Bioprocessing
- • Convective Mass Transfer
- • Oxygen Transfer in Cell Cultures
- • Oxygen Uptake by Cells
- • Factors Affecting Oxygen Transfer
- • Measuring Dissolved Oxygen Concentration and Oxygen Solubility
- • Oxygen Mass Transfer Correlation
- • Measurement of kLa
- • Application and Design of Mass Transfer Systems
- • Plug Flow Reactors
- • Immobilized Systems
- • Worked Examples
- • Chapter Summary
Chapter 10: Bioreactor Heat Transfer
- • Heat Transfer Equipment
- • Mechanisms of Heat Transfer
- • Conduction
- • Heat Transfer Between Fluids
- • Application and Design of Heat Transfer Systems
- • Worked Examples
- • Chapter Summary
Chapter 11: Unit Operations/Downstream Processing
- • Overview of Processes and Cell Removal Operations
- • Filtration
- • Centrifugation
- • Cell Disruption
- • Extraction
- • Precipitation
- • Adsorption
- • Chromatography
- • Crystallization
- • Drying
- • Worked Examples
- • Chapter Summary
Chapter 12: Genetic and Evolutionary Engineering of Organisms for Bioprocessing
- • Introduction
- • Strategies and Systems
- • Metabolic Engineering
- • Metabolic Modeling
- • Integration of Process and Organism Design
- • Protein Engineering
- • Chapter Summary
Chapter 13: Process Engineering and Design of Bioprocesses
- • Sustainable Bioprocesses
- • Biobased Products and Feedstocks
- • Sustainable Bioprocess Example 1: Starch-Based Ethanol
- • Sustainable Bioprocess Example 2: Anaerobic Digestion
- • Sustainable Bioprocess Example 3: Bio-Based PLA
- • Environmental Engineering Processes
- • Environmental Engineering Background
- • Environmental Engineering Process Example 1: Wastewater Treatment
- • Biomedical Engineering Processes
- • Biomedical Engineering Process Example 1: Therapeutic Proteins
- • Biomedical Engineering Process Example 2: Monoclonal Antibodies
- • Chapter Summary
Chapter A: Common Unit Conversions
Chapter B: Conversion Factors
Chapter C: Ideal Gas Constants
Chapter D: Physical and Chemical Property Data