Epilepsy: A Comprehensive Textbook

Name: Epilepsy: A Comprehensive Textbook
Price: 635.99 USD
Availability: InStock
ISBN: 9781975105525

by Jerome Engel Jr, Solomon L. Moshé

3rd Edition

Publisher: Wolters Kluwer Health

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Book Details

Print ISBN	9781975105525
eText ISBN	9781975105549
Publisher	Wolters Kluwer Health
Publishing Year	2024
Edition	3rd Edition
Language	English
Pages	3998

Epilepsy: A Comprehensive Textbook, 3rd Edition establishes a thorough scientific and clinical framework for evaluating seizure disorders. Edited by Jerome Engel, Jr., Solomon L. Moshé, Aristea S. Galanopoulou, John M. Stern, Alexis Arzimanoglou, Jacqueline A. French, Renzo Guerrini, Andres M. Kanner, and Istvan Mody, the reference outlines basic disease processes while supporting evidence-based clinical practices.

The content encompasses 365 chapters that systematically connect basic laboratory science with bedside management. Specialized sections address molecular biology, genetic etiologies, and the diagnostic evaluation of individuals with seizures. Further thematic modules detail pharmacologic regimens, alternative therapies, surgical procedures including neuromodulation, and global health care delivery.

Published by Wolters Kluwer Health in 2024, the compilation incorporates insights from expert contributors affiliated with nearly 300 institutions across 48 countries. This broad international foundation provides a practical reference suited for health science libraries, advanced neurology researchers, and clinical practice teams.

Chapter 1: Overview: Epidemiology and Pathology of Seizures and Epilepsy
Chapter 2: Epilepsy: Historical Perspectives
Chapter 3: Incidence and Prevalence of Seizures and Epilepsy
Chapter 4: Epidemiology of Epilepsy in Low- and Middle-Income Countries
Chapter 5: Etiology and Risk Factors for Seizures and Epilepsy
Chapter 6: The Comorbidities in Epilepsy
Chapter 7: Natural History and Prognosis of Epilepsy
Chapter 8: Epidemiology of Acute Symptomatic Seizures
Chapter 9: Seizure Precipitants
Chapter 10: The Mortality of Epilepsy
Chapter 11: General Neuropathology of Epilepsy
Chapter 12: Neuropathology of Hippocampal Sclerosis
Chapter 13: Neuropathology of Developmental Disorders Associated With Epilepsy
Chapter 14: Neuropathology of Brain Tumors Associated With Epilepsy
Chapter 15: Neuropathology of Vascular Lesions Associated With Epilepsy
Chapter 16: Overview: Genetics in Epilepsy
Chapter 17: Genetic Epidemiology in Epilepsy
Chapter 18: Genetic Architecture of the Epilepsies
Chapter 19: Single Gene Epilepsies
Chapter 20: How to Interpret and Act on Clinical Exomes in Epilepsy
Chapter 21: Familial Epilepsies in the First Year of Life
Chapter 22: Developmental and Epileptic Encephalopathies
Chapter 23: Genetic Generalized Epilepsies
Chapter 24: Genetic Encephalopathies With Epilepsy as a Main Feature
Chapter 25: Genetic Testing and Counseling for the Epilepsies
Chapter 26: Overview: Neurobiology of Epilepsy
Chapter 27: Transcriptional Channelopathies in Genetic and Acquired Epilepsies
Chapter 28: Principal Cell Heterogeneity in Malformations of Cortical Development and Acquired Epilepsy
Chapter 29: Mechanisms of Neuronal Excitation Leading to Synchrony
Chapter 30: Interneuron Diversity in Epilepsy: Challenges and Progress
Chapter 31: Mechanisms of Neuronal Inhibition Leading to Synchrony
Chapter 32: Neurons and Circuits During Brain Development
Chapter 33: Metabolism, Reactive Oxygen Species, and Epilepsy
Chapter 34: Dendritic Mechanisms of Excitability
Chapter 35: Thalamocortical Organization and Function: New Insights and Implications for Epilepsy
Chapter 36: Mechanisms of Seizure Initiation and Propagation
Chapter 37: Seizures and Networks in the Human Focal Epilepsies: Beyond the Animal Models
Chapter 38: Temporal Coordination: A Key to Understand Cognitive and Behavioral Deficits in Epilepsy
Chapter 39: Epilepsy and Consciousness
Chapter 40: Activating and Recording Neuronal Ensembles
Chapter 41: Genetically Encoded Probes for Optical Measurement of Neuronal Excitability and Synchrony
Chapter 42: Fast Rhythms in Epilepsies
Chapter 43: Miniaturized Microscopy as a Tool to Track Neuronal Population Dynamics in Epilepsy Models
Chapter 44: Seizure Control Through Closed-Loop Systems
Chapter 45: Biomarkers
Chapter 46: Comorbidities as Prognostic Factors for Epileptogenesis
Chapter 47: Use of Human Pluripotent Stem Cells in Epilepsy Research
Chapter 48: Novel Roles of Myelination in Neural Circuit Plasticity and Implications for Epilepsy
Chapter 49: Role of Dysfunctional Astrocytes in Epileptogenesis
Chapter 50: Neurovascular Inflammation in Epilepsy
Chapter 51: The Blood–Brain Barrier and Epilepsies
Chapter 52: The mTOR Pathway in Epileptogenesis
Chapter 53: Epigenetic Mechanisms in Epilepsy
Chapter 54: Purinergic Signaling in Epilepsy
Chapter 55: Neurotrophic Factors in Epilepsy
Chapter 56: Neurogenesis in Epilepsy
Chapter 57: Somatic Mosaicism in Focal Malformations of Cortical Development
Chapter 58: The Microbiota–Gut–Brain Axis and Epilepsy
Chapter 59: Overview: Translational and Clinical Biology of Seizures and Epilepsy
Chapter 60: Refinement of Rodent Models of Seizures and Epilepsy
Chapter 61: What do Models Model in Epilepsy?
Chapter 62: Translational Epilepsy Research: Progress, Challenges, and Future
Chapter 63: Age and Sex in the Neurobiology of Epilepsies in Animal Models
Chapter 64: Gender in Clinical Biology of Epilepsy
Chapter 65: Age and Clinical Biology of Epilepsy: Adults
Chapter 66: Age and Clinical Biology of Epilepsy: Infants
Chapter 67: Chronobiology of Epilepsy
Chapter 68: Sleep and Epilepsy
Chapter 69: Breathing and Autonomic Disturbances During Seizures
Chapter 70: Sudden Unexpected Death in Epilepsy (SUDEP)
Chapter 71: Stress and Epilepsy
Chapter 72: Seizures and Epilepsy in General Medical Disorders
Chapter 73: Medical Conditions in Children With Epilepsy
Chapter 74: Neurodegenerative Disorders and Epileptogenesis
Chapter 75: Anesthesia for Procedures in Patients With Epilepsy
Chapter 76: Hormone Changes in Epilepsy
Chapter 77: Effects of Hormones on Seizure Expression
Chapter 78: Disorders of Reproduction and Fertility in Epilepsy
Chapter 79: Sexuality in Epilepsy
Chapter 80: Maternal Outcomes During Pregnancy in Women With Epilepsy
Chapter 81: Consequences of Seizures