Genetics of Bone Biology and Skeletal Disease

Name: Genetics of Bone Biology and Skeletal Disease
Price: 230 USD
Availability: InStock
ISBN: 9780443136832

by Rajesh V. Thakker, Michael P. Whyte, John A. Eisman, Takashi Igarashi

3rd Edition

Publisher: Academic Press

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Genetics Life Sciences

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Book Details

Print ISBN	9780443136832
eText ISBN	9780443136849
Publisher	Academic Press
Publishing Year	2026
Edition	3rd Edition
Language	English
Pages	900

Genetics of Bone Biology and Skeletal Disease, 3rd Edition, is an academic reference work dedicated to skeletal genetics, mineral metabolism, and disease mechanisms. Published by Academic Press in 2026 and edited by Rajesh V. Thakker, Michael P. Whyte, John A. Eisman, and Takashi Igarashi, this 900-page volume provides grounding for researchers, practitioners, graduate students, and medical fellows.

The content includes general introductory chapters covering bone biology, genetics, and epigenetics to establish basic biological principles. It further details genome-wide association studies (GWAS) along with genomic profiling to explain modern disease identification techniques.

A defining feature of the text is its coverage of both monogenic and polygenic skeletal and joint disorders. This focused material supports advanced graduate coursework and specialized clinical practice for professionals who treat individuals with bone, joint, and associated endocrine disorders.

Chapter 1: Introduction to genetics of skeletal and mineral metabolic diseases
Chapter 2: Genome sequencing and Big Data analysis
Chapter 3: Genome-wide association studies in bone mineral density: principles, practicalities, progress, and potential in bone and mineral disorders, including osteoporosis
Chapter 4: Functional genomics
Chapter 5: Epigenetics
Chapter 6: Bone-on-chip models
Chapter 7: Mouse models: approaches to generate in vivo models for hereditary disorders of mineral and skeletal homeostasis
Chapter 8: Bone quality characteristics in zebrafish disease models
Chapter 9: Prospects of gene therapy for skeletal diseases
Chapter 10: Genetics and pharmacogenetics of osteoporosis: personalized medicine outlook
Chapter 11: Biology of bone and cartilage
Chapter 12: Overview of bone structure and strength
Chapter 13: Overview of joint and cartilage biology
Chapter 14: Osteocyte biology
Chapter 15: Bone marrow stromal cells/skeletal stem cells
Chapter 16: Osteoimmunology
Chapter 17: Genetics of bone fat and energy regulation
Chapter 18: Central regulation of bone remodeling, genetic evidence
Chapter 19: Integrating endocrine and paracrine influences on bone: lessons from parathyroid hormone and parathyroid hormone-related protein
Chapter 20: The fibroblast growth factor-Klotho endocrine system in health and disease
Chapter 21: Mechano-adaptation and mechano-sensing in skeletal biology
Chapter 22: The hypoxia signaling pathway in the skeleton
Chapter 23: Chronobiology and clock genes in bone and mineral metabolism
Chapter 24: Osteoblastic cell senescence and their contribution to metabolic bone diseases
Chapter 25: Fetal control of calcium and phosphate homeostasis
Chapter 26: Control of mineral and skeletal homeostasis during pregnancy and lactation
Chapter 27: Gene discoveries and novel therapies in monogenic low and high bone mass disorders
Chapter 28: Osteogenesis imperfecta
Chapter 29: Osteoarthritis: genetic studies of monogenic and complex forms
Chapter 30: Skeletal dysplasias
Chapter 31: Sclerosing bone dysplasias
Chapter 32: Mendelian disorders of RANKL/RANK/OPG/NF-κB signaling
Chapter 33: Hypophosphatasia and how alkaline phosphatase promotes mineralization
Chapter 34: Fibrodysplasia ossificans progressiva
Chapter 35: The melorheostoses
Chapter 36: Disorders and mechanisms of ectopic calcification
Chapter 37: Hyperparathyroidism
Chapter 38: Hypoparathyroidism
Chapter 39: Gsα, pseudohypoparathyroidism, fibrous dysplasia, and McCune-Albright syndrome
Chapter 40: Genetic disorders caused by mutations in the parathyroid hormone/parathyroid hormone-related peptide receptor, its ligands, and downstream effector molecules
Chapter 41: The calcium-sensing receptor
Chapter 42: Multiple endocrine neoplasia syndromes
Chapter 43: Multiple endocrine and other organ neoplasia syndromes
Chapter 44: Genetic disorders of vitamin D metabolism and action
Chapter 45: X-linked hypophosphatemias
Chapter 46: Autosomal hypophosphatemias
Chapter 47: Genetics of hypercalciuria and kidney stones