Handbook of Proteolytic Enzymes

Name: Handbook of Proteolytic Enzymes
Price: 350 USD
Availability: InStock
ISBN: 9780443288494

Metallopeptidases

by Neil D. Rawlings, David S. Auld

4th Edition

Publisher: Academic Press

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Book Details

Print ISBN	9780443288494
eText ISBN	9780443288500
Publisher	Academic Press
Publishing Year	2025
Edition	4th Edition
Language	English
Pages	2418

The Handbook of Proteolytic Enzymes, 4th Edition provides structured scientific reference data on metallopeptidases to support precise enzyme classification and molecular analysis. Editors Neil D. Rawlings and David S. Auld present systematic profiles covering catalytic mechanisms, substrate interactions, and enzyme classifications. This volume establishes a clear framework for examining how specific peptidases function within biochemical pathways and complex cellular environments.

The content synthesizes core thematic areas including the structural chemistry of peptidases, inhibitors of proteolytic enzymes, and practical applications in biocatalysis. Readers trace how chemical structures govern enzymatic activity, connecting fundamental enzyme mechanisms to broader research in therapeutic development and drug trials.

A primary structural feature includes direct links to PubMed and MEROPS databases to facilitate efficient literature lookup. This reference fits the needs of biochemists, molecular biologists, cell biologists, medical chemists, organic chemists, pharmacologists, clinician scientists, pharmaceutical researchers, and students of biochemical sciences.

Chapter 1: Introduction: metallopeptidases and their clans
Chapter 2: Catalytic mechanisms for metallopeptidases
Chapter 3: Aminopeptidase N
Chapter 4: Glutamyl aminopeptidase
Chapter 5: Cystinyl aminopeptidase (oxytocinase)
Chapter 6: Aminopeptidase Q
Chapter 7: Pyroglutamyl-peptidase II
Chapter 8: Aminopeptidase ERAP-1
Chapter 9: Endoplasmic reticulum aminopeptidase 2
Chapter 10: Leukotriene A 4 hydrolase
Chapter 11: Tripeptide aminopeptidase
Chapter 12: Cytosol alanyl aminopeptidase
Chapter 13: Aminopeptidase B
Chapter 14: Aminopeptidase Ey
Chapter 15: Insect aminopeptidase N
Chapter 16: Aminopeptidase H11 (nematode)
Chapter 17: Yeast aminopeptidases Ape2, Aap1′, and TMA108
Chapter 18: Leukotriene A4 hydrolase (Saccharomyces cerevisiae)
Chapter 19: PfA-M1 aminopeptidase (Plasmodium falciparum)
Chapter 20: Lysyl aminopeptidase (bacteria)
Chapter 21: Alanyl aminopeptidase (bacterial-type)
Chapter 22: Aminopeptidase N (Streptomyces lividans)
Chapter 23: The cold-active M1 aminopeptidase from the Arctic bacterium Colwellia psychrerythraea
Chapter 24: Tricorn interacting factors F2 and F3
Chapter 25: Peptidyl-dipeptidase A/angiotensin I-converting enzyme
Chapter 26: Angiotensin-converting enzyme-2