Retinoic Acids in Cancer Therapy

Name: Retinoic Acids in Cancer Therapy
Price: 175 USD
Availability: InStock
ISBN: 9780443223051

Mechanisms of Sensitivity, Resistance, and Methods of Delivery

by Saeid Ghavami, Ali Zarrabi, Marco Cordani

1st Edition

Publisher: Academic Press

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Book Details

Print ISBN	9780443223051
eText ISBN	9780443223044
Publisher	Academic Press
Publishing Year	2026
Edition	1st Edition
Language	English
Pages	408

The 1st Edition of Retinoic Acids in Cancer Therapy provides a focused examination of All-Trans Retinoic Acid (ATRA) and its application in oncology. Edited by Saeid Ghavami, Ali Zarrabi, and Marco Cordani, this volume investigates how cellular pathways determine drug sensitivity and influence therapeutic response in malignant cells.

The text synthesizes key therapeutic themes, analyzing cellular determinants of sensitivity alongside mechanisms of drug resistance in aggressive tumors. It examines biological interactions involving intrinsic and extrinsic apoptosis, autophagy, and the unfolded protein response during ATRA-induced cell death. Further coverage addresses multi-target-directed ligands, modulation of cancer stem cell fate, and the application of artificial intelligence and machine learning models to predict treatment outcomes.

Organized across 15 detailed chapters, the work includes dedicated Learning Objectives and a 'What We Learn' section in every chapter to guide structural comprehension. This reference supports cancer research scientists, cell biologists, oncologists, physicians, pharmacologists, biotech companies, and academic trainees seeking an evidence-based foundation in retinoid therapeutics.

Chapter 1: Molecular structure and biological properties of all-trans retinoic acid
Chapter 2: Emerging frontiers in drug development of all-trans retinoic acid and its derivatives
Chapter 3: Cellular and molecular determinants of all trans retinoic acid sensitivity in different cancers
Chapter 4: Apoptosis, autophagy, and unfolded protein response and their impact on all-trans retinoic acid-induced toxicity in cancer cells
Chapter 5: Mechanisms of resistance to all-trans retinoic acid and use of multi-target-directed ligand to fight against resistance
Chapter 6: Nanocarrier systems for targeted delivery of all-trans retinoic acid: design and mechanisms
Chapter 7: Advanced delivery systems for all-trans retinoic acid: challenges and opportunities in pharmacokinetics and bioavailability
Chapter 8: Mechanisms of sensitivity, resistance, and methods of delivery
Chapter 9: Efficiency of all-trans retinoic acid on gastric cancer
Chapter 10: All-trans retinoic acid and its role in glioblastoma therapy
Chapter 11: All-trans retinoic acid and vitamin A in neurodegeneration: from oncology to neuroprotection
Chapter 12: Efficiency of all-trans retinoic acid in liver cancer
Chapter 13: Efficiency of all-trans retinoic acid on colon cancer
Chapter 14: Retinoic acids in head and neck cancer therapy: mechanisms of sensitivity, resistance, and methods of delivery
Chapter 15: Role of artificial intelligence and machine learning in predicting all-trans retinoic acid treatment outcomes