Retinoids in Development and Disease

Retinoids in Development and Disease, 1st Edition, edited by Norbert Ghyselinck and Gregg Duester, presents a detailed examination of retinoic acid signaling from germ cells to adult organisms during normal growth and pathological conditions. The volume outlines the biochemical mechanisms through which vitamin A derivatives regulate embryonic pattern formation and long-term tissue stability across mammalian systems.

The text synthesizes core research on early retinoic acid signaling in body axis organization, forelimb domain definition, and eye field specification. Additional chapters examine retinoic acid self-regulation through signaling robustness networks, the metabolic roles of cellular retinoic acid binding proteins, meiotic initiation in the fetal ovary occurring without retinoic acid receptors, and retinoic acid actions on progenitor cells in the testis.

Published by Academic Press in January 2025 as Volume 161 of the Current Topics in Developmental Biology series (hardback ISBN 9780323917001), this work provides structured instruction for readers seeking to master standard retinoid pathways and the pathological breakdowns that occur during signaling dysfunction.