
Systemic Lupus Erythematosus
Basic, Applied and Clinical Aspects
by George C. Tsokos
3rd Edition
Publisher: Academic Press
Book Details
| Print ISBN | 9780443339578 |
| eText ISBN | 9780443339585 |
| Publisher | Academic Press |
| Publishing Year | 2026 |
| Edition | 3rd Edition |
| Language | English |
Systemic Lupus Erythematosus, 3rd Edition, presents a scientific and clinical reference covering the biological foundations and management of systemic lupus erythematosus. Published by Academic Press, this volume provides basic scientists, clinicians, rheumatologists, dermatologists, nephrologists, immunologists, and allergists with systematic information regarding disease mechanisms and medical care.
The text synthesizes major thematic areas including disease epidemiology, diagnostic criteria, underlying pathogenesis, pathways of tissue damage, clinical manifestations, and treatment options. It details the specific cellular, molecular, genetic, and environmental factors that instigate and drive systemic lupus erythematosus across human tissue systems and physiological pathways.
As a multi-specialty medical volume, the text functions as an essential reference work for hospital libraries supporting clinical staff and academic research personnel. It connects fundamental immunological research directly to clinical practice for specialists managing complex autoimmune diseases.
Table of Contents
Chapter 1: Introduction
Chapter 2: The patient
Chapter 3: Practicing law with lupus: the story of a patient
Chapter 4: Epidemiology
Chapter 5: Measuring disease activity
Chapter 6: Disease development and outcome
Chapter 7: Socioeconomic aspects of SLE
Chapter 8: Biomarkers in systemic lupus erythematosus
Chapter 9: Biomarkers in lupus nephritis
Chapter 10: Overview of the pathogenesis of systemic lupus erythematosus
Chapter 11: System lupus erythematosus and the environment
Chapter 12: Genes and genetics in human SLE
Chapter 13: Monogenic lupus
Chapter 14: Hormones
Chapter 15: Clinical aspects of the complement system in systemic lupus erythematosus
Chapter 16: T cells
Chapter 17: B cells in SLE
Chapter 18: Neutrophils in systemic lupus erythematosus
Chapter 19: The role of dendritic cells in systemic lupus erythematosus
Chapter 20: Platelets in lupus
Chapter 21: Cytokines
Chapter 22: RNA/DNA sensing in SLE—Toll-like receptors and beyond
Chapter 23: The role of interferons in systemic lupus erythematosus
Chapter 24: Fcγ receptors in autoimmunity and end organ damage
Chapter 25: Apoptosis, autophagy, and necrosis
Chapter 26: Infections in early systemic lupus erythematosus pathogenesis
Chapter 27: Microbiota influences on systemic lupus erythematosus and Sjögren’s syndrome
Chapter 28: Origin of autoantibodies
Chapter 29: Anti-DNA antibodies
Chapter 30: Antihistone and antispliceosome antibodies
Chapter 31: Immune complexes in systemic lupus erythematosus
Chapter 32: MicroRNA in systemic lupus erythematosus
Chapter 33: Metabolic control of lupus pathogenesis
Chapter 34: Epigenetics
Chapter 35: What do mouse models and genetics teach us about human SLE?
Chapter 36: Mechanisms of renal damage in systemic lupus erythematosus
Chapter 37: Mechanisms of vascular damage in systemic lupus erythematosus
Chapter 38: The mechanism of skin damage
Chapter 39: Pathogenesis of tissue injury in the brain in patients with systemic lupus erythematosus
Chapter 40: Constitutional symptoms and fatigue in systemic lupus erythematosus
Chapter 41: The musculoskeletal system in SLE
Chapter 42: Cutaneous lupus erythematosus
Chapter 43: The clinical evaluation of kidney disease in systemic lupus erythematosus
Chapter 44: The pathology of lupus nephritis
Chapter 45: Cardiovascular disease in systemic lupus erythematosus: an update
Chapter 46: The lung in systemic lupus erythematosus
Chapter 47: Gastrointestinal, hepatic, and pancreatic disorders in systemic lupus erythematosus
Chapter 48: Systemic lupus erythematosus and infections
Chapter 49: Malignancies in systemic lupus erythematosus
Chapter 50: The nervous system in systemic lupus erythematosus
Chapter 51: Psychiatric lupus
Chapter 52: Overlap syndromes
Chapter 53: Systemic lupus erythematosus and the eye
Chapter 54: Fertility and pregnancy in systemic lupus erythematosus
Chapter 55: Neonatal lupus: Clinical spectrum, biomarkers, pathogenesis, and approach to treatment
Chapter 56: Incomplete lupus syndromes
Chapter 57: Lupus in children and adolescents
Chapter 58: Drug-induced lupus
Chapter 59: Vasculitis in lupus
Chapter 60: Accrual of organ damage in lupus
Chapter 61: Pathogenesis of antiphospholipid syndrome
Chapter 62: Antibodies and diagnostic tests in antiphospholipid syndrome
Chapter 63: Clinical manifestations
Chapter 64: Nonsteroidal anti-inflammatory drugs in systemic lupus erythematosus
Chapter 65: Value of antimalarial drugs in the treatment of lupus,
Chapter 66: Systemic glucocorticoids
Chapter 67: Cytotoxic drug treatment
Chapter 68: Treatment of antiphospholipid syndrome
Chapter 69: New treatments of systemic lupus erythematosus
Chapter 70: Cell therapies in lupus
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