Translational Gastroenterology
by Adam E.M. Eltorai, Tao Liu, Devendra Mehta, Karoly Horvath
1st Edition
Publisher: Academic Press
Book Details
| Print ISBN | 9780128214268 |
| eText ISBN | 9780128214275 |
| Publisher | Academic Press |
| Publishing Year | 2025 |
| Edition | 1st Edition |
| Language | English |
| Pages | 516 |
Translational Gastroenterology, 1st Edition, provides a comprehensive overview of evidence-based medicine applied to clinical research design in gastroenterology. Published in 2025 by Academic Press, this volume is edited by Adam E.M. Eltorai, Tao Liu, Devendra Mehta, and Karoly Horvath to assist investigators in developing valid research questions and protocols.
The book structures its methodological coverage across essential epidemiological and experimental study types. It details the setup and evaluation of case-control studies, prospective cohort studies, randomized trials, and reliability studies. Additionally, it addresses methods for the critical appraisal of published literature and the precise evaluation of clinical outcome measurements.
Practical guidance on grant writing and securing research funding helps investigators prepare competitive proposals. This work offers structured support for students in master's programs in clinical investigation, basic scientists translating bench findings into medical practice, practicing gastroenterologists, and active clinical researchers.
Table of Contents
Chapter PART I: CONCEPT
Chapter 1: Introduction to clinical research
Chapter 2: The question
Chapter 3: Study population
Chapter 4: Outcome measurements
Chapter PART II: STUDY TYPES
Chapter 5: Design principles
Chapter 6: Case series
Chapter 7: Case-control study
Chapter 8: Cohort study
Chapter 9: Cross-section study
Chapter 10: Clinical trials
Chapter 11: Meta-analysis
Chapter 12: Cost-effectiveness study
Chapter 13: Diagnostic test evaluation
Chapter 14: Reliability study
Chapter 15: Database studies
Chapter 16: Surveys and questionnaires
Chapter 17: Qualitative methods and mixed methods
- • Definition of the study type
Chapter PART III: CLINICAL TRIALS
Chapter 17: Randomized control
Chapter 18: Nonrandomized control
Chapter 19: Historical control
Chapter 20: Cross-over
Chapter 21: Withdrawal studies
Chapter 22: Factorial design
Chapter 23: Group allocation
Chapter 24: Hybrid design
Chapter 25: Large, pragmatic
Chapter 26: Equivalence and noninferiority
Chapter 27: Adaptive
Chapter 28: Randomization
Chapter 30: Multicenter considerations
- • Study design and practical considerations
Chapter PART IV: PLANNING
Chapter 31: Optimizing the question
Chapter 32: Meaningful outcome measurements
Chapter 33: Sample size
- • Power analysis
Chapter 34: Budgeting
- • Funding, timeline, personnel, materials
Chapter 35: Ethics and review boards
Chapter 36: Regulatory considerations for new drugs and devices
Chapter 37: Funding approaches
Chapter 38: Research team
Chapter 39: Subject recruitment
Chapter 40: Data management
Chapter 41: Quality control
Chapter 42: Report forms
Chapter 43: Subject adherence
Chapter 44: Survival analysis
Chapter 45: Monitoring committee in clinical trials
Chapter PART V: STATISTICAL PRINCIPLES
Chapter 46: Presenting data
Chapter 47: Common issues in analysis
Chapter 48: Basic statistical principles
Chapter 49: Distributions
- • Description, examples, implications in analysis.
Chapter 50: Hypotheses and error types
Chapter 51: Power
- • Detecting effects
Chapter 52: Regression
- • Explanation
Chapter 53: t-test
- • Explanation
Chapter 54: Chi-square
- • Explanation
Chapter 55: Analysis of variance
- • Explanation
Chapter 56: Correlation
- • Explanation
Chapter 57: Biases
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