Unlocking Sirtuins

Unlocking Sirtuins: Cellular Biology to Translational Research, 1st Edition, edited by Pranav Kumar Prabhakar and Sumel Ashique, presents an examination of sirtuin biology organized into six main parts from basic principles to translational research. Published by Academic Press, this 2026 text connects foundational enzymatic mechanisms with human disease research for cell biology researchers, molecular biologists, and clinicians.

The work synthesizes core physiological functions, detailing NAD+-dependent enzymatic mechanisms alongside NAD+ precursors such as NMN and NR. The coverage extends to sirtuin involvement in energy homeostasis, glucose and lipid metabolism, caloric restriction, and fasting responses, while also addressing sirtuin pathways in DNA repair, genome maintenance, mitochondrial health, cellular senescence, and longevity.

As a key technical feature, the volume outlines experimental tools for sirtuin modulation ranging from CRISPR to chemical biology. This practical framework supports biochemistry scientists, pharmacology researchers, biotechnology specialists, and translational medicine professionals investigating sirtuin target modulation.