New Opioid Receptor Modulators and Agonists

Name: New Opioid Receptor Modulators and Agonists
Price: 165 USD
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ISBN: 9780443265044

Relevance for Pain and Opioid Use Disorder Management

by Alan David Kaye, Scott Edwards

1st Edition

Publisher: Academic Press

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Book Details

Print ISBN	9780443265044
eText ISBN	9780443265051
Publisher	Academic Press
Publishing Year	2025
Edition	1st Edition
Language	English
Pages	238

In New Opioid Receptor Modulators and Agonists, 1st Edition, editors Alan David Kaye and Scott Edwards compile focused scientific analyses addressing the chemical design and therapeutic implementation of opioid receptor modulators. Written primarily for biomedical researchers with relevant applications for practicing clinicians, the book evaluates how targeted ligand structures and molecular mechanisms improve therapeutic strategies for managing pain, substance misuse, and addiction.

The content explores the biochemical rationale for identifying allosteric binding sites on opioid receptors, outlining key principles for engineering allosteric modulators. In addition, the text connects pharmacological principles to pharmacogenomics and precision medicine, providing readers with insights into drug metabolism, patient-specific variability, and the management of opioid-associated syndromes and related comorbidities.

To address clinical safety challenges, the book highlights technological advancements in abuse-deterrent opioid formulations and experimental opioid vaccines. This structured synthesis provides researchers and medical professionals with a reliable reference for evaluating modern opioid ligands and targeted treatment modalities.

Chapter 1: Making Sense of the Complexities of Opioid Receptor Function: Evolving Appreciation of Opioid Receptor Classification and Basic Characteristics
Chapter 2: Allostery at Opioid Receptors: Modulation with Small Molecule Ligands, Regulator of G-Protein Signaling (RGS) Protein Modulation of Opioid Receptor Signaling as a Potential Target for Pain Management
Chapter 3: Opioid Agonist and Antagonist Pharmacology: Phenylpiperidines, Tramadol, Buprenoprhine, Methadone, and Codeine Derivatives
Chapter 4: Pharmacogenomics/Precision Medicine: Opioid-related Interactions and Metabolism Considerations
Chapter 5: Opioid-associated Syndromes and Comorbidities
Chapter 6: Opioid-induced Hyperalgesia
Chapter 7: Drug Facts: Novel Synthetic Opioids
Chapter 8: Roots of the Opioid Crisis: Description of the Four Waves of the Opioid Epidemic
Chapter 9: Opioids and Risk of Dependency: Neurobiology of Opioid Use Disorder
Chapter 10: Opioids and Risk of Dependency: Responsibilities of Healthcare Workers, Manufacturers, and Pharmacists
Chapter 11: CDC Guidelines for Chronic Pain in the Adult, Including Newer Guidelines Against Co-prescription with Benzodiazepines.
Chapter 12: Commonly Prescribed Opioids and Adjuvants in Acute and Chronic Pain Management
Chapter 13: Clinical Considerations of Commonly Prescribed Medications in Substance Abuse Management (e.g., buprenorphine (how is it prescribed); methadone (concerns over prolonged QT EKG prior to administration; urine drug screens
Chapter 14: The Role of Naltrexone and Novel Preparations for Substance Abuse and Pain Management
Chapter 15: Palliative Care for Cancer and Considerations for Opioid-mediated Suppression of Natural Killer Cells
Chapter 16: Abuse Deterrent Formulations of Opioids and Opioid Vaccines
Chapter 17: Opioid Detoxification Techniques