Basic Pharmacokinetics

Name: Basic Pharmacokinetics
Price: 54.99 USD
Availability: InStock
ISBN: 9780367752156

by Mohsen A. Hedaya

3rd Edition

Publisher: Routledge

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Pharmacology

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Book Details

Print ISBN	9780367752156
eText ISBN	9781000922011
Publisher	Routledge
Publishing Year	2024
Edition	3rd Edition
Language	English
Pages	464

Basic Pharmacokinetics, 3rd Edition is an academic textbook designed to introduce beginner learners to foundational principles of drug absorption, distribution, metabolism, and excretion. The text establishes the essential mathematical framework needed to evaluate how therapeutic compounds move through biological systems over time.

The volume focuses on quantitative pharmacokinetic relations and the functional interplay between parameters across different administration routes. Detailed chapters explore single intravenous bolus dosing, extravascular absorption considerations, systemic clearance, and the overall rate of drug elimination. Further sections examine bioavailability determination, bioequivalence standards, steady-state mechanics, and kinetic patterns resulting from constant rate infusions or multiple drug administration schedules.

To assist readers in calculating pharmacokinetic parameters, the text includes dedicated practice problems alongside step-by-step solved examples. Bullet point summaries embedded within the text demonstrate direct clinical practice applications, offering targeted learning support for students enrolled in pharmacy, pharmacology, and pharmaceutical science programs.

Chapter 1: Introduction to Pharmacokinetics
Chapter 2: Drug Pharmacokinetics Following Single Intravenous Bolus Administration: Drug Distribution
Chapter 3: Drug Pharmacokinetics Following a Single IV Bolus Administration: Drug Clearance
Chapter 4: Drug Pharmacokinetics Following Single IV Bolus Administration: The Rate of Drug Elimination
Chapter 5: Drug Absorption Following Extravascular Administration: Biological, Physicochemical, and Formulation Considerations
Chapter 6: Drug Pharmacokinetics Following Single Oral Drug Administration: The Rate of Drug Absorption
Chapter 7: Drug Pharmacokinetics Following Single Oral Drug Administration: The Extent of Drug Absorption
Chapter 8: Bioequivalence
Chapter 9: Drug Pharmacokinetics during Constant Rate IV Infusion, the Steady State concept
Chapter 10: Steady State during Multiple Drug Administration
Chapter 11: Renal Drug Excretion
Chapter 12: Metabolite Pharmacokinetics
Chapter 13: Nonlinear Pharmacokinetics
Chapter 14: Multicompartment Pharmacokinetic Models
Chapter 15: Drug Pharmacokinetics Following Administration by Intermittent Intravenous Infusions
Chapter 16: Physiological Approach to Hepatic Clearance
Chapter 17: Pharmacokinetics in Patients with Eliminating Organ Dysfunction
Chapter 18: Noncompartmental Approach in Pharmacokinetic Data Analysis
Chapter 19: Pharmacokinetic-Pharmacodynamic Modeling
Chapter 20: Pharmacogenetics: The Genetic Basis of Pharmacokinetic and Pharmacodynamic Variability
Chapter 21: Therapeutic Drug Monitoring
Chapter 22: Pharmacometic Applications in Drug Development and Individualization of Drug Therapy
Chapter 23: Answer to Practice Problems