
Direct-Acting Antivirals against Hepatitis C
Current Issues and Future Perspectives
by Mohamed Mahmoud Zakaria El-Kassas
1st Edition
Publisher: Academic Press
Book Details
| Print ISBN | 9780443413636 |
| eText ISBN | 9780443413643 |
| Publisher | Academic Press |
| Publishing Year | 2026 |
| Edition | 1st Edition |
| Language | English |
Direct-Acting Antivirals against Hepatitis C, 1st Edition, presents a dedicated academic reference on chronic hepatitis C management and direct-acting antiviral therapies. Designed for clinicians, researchers, practitioners, and advanced students specializing in hepatology and infectious diseases, this volume examines the fundamental biological mechanisms, clinical efficacy, and future potential of direct-acting antiviral interventions.
The text systematically reviews virus-host interactions, host-related determinants, intracellular signaling pathways, and established direct-acting antiviral drug classes. It analyzes comparative clinical efficacy data, treatment safety profiles, and patient tolerability across different therapeutic regimens, while assessing health benefits realized beyond initial virological response.
By incorporating expert scientific insights from specialists across immunology, pharmacology, virology, and clinical hepatology, this reference supplies grounded evidence to guide academic study and professional practice. The work provides practical analytical context for medical specialists and clinical research teams working to evaluate and optimize viral hepatitis treatment protocols.
Table of Contents
Chapter 1: Hepatitis C virus: Overview
Chapter 2: HCV-host interactions: Virus specific factors, virus host related determinants, and intracellular signaling
Chapter 3: Introduction to direct-acting antivirals: Mechanisms of action and different classes
Chapter 4: Clinical efficacy of different DAAs regimens
Chapter 5: Safety and tolerability of different DAAs regimens
Chapter 6: Benefits of treating HCV by DAAs beyond virological response
Chapter 7: Current landscape and guidelines of DAAs treatment in general population
Chapter 8: Individualized treatment approaches in various special patient populations
Chapter 9: Antiviral resistance in hepatitis C and DAA therapy
Chapter 10: DAA therapy and hepatocellular carcinoma
Chapter 11: Limitations and unmet needs in DAAs therapy
Chapter 12: Emerging therapeutic strategies and future directions
Chapter 13: Access to DAA therapy, and the role of DAAs in targeted HCV elimination
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