Hematology
Basic Principles and Practice
by Leslie E. Silberstein, John Anastasi
7th Edition
Publisher: Elsevier
Book Details
| Print ISBN | 9780323357623 |
| eText ISBN | 9780323509398 |
| Publisher | Elsevier |
| Publishing Year | 2017 |
| Edition | 7th Edition |
| Language | English |
| Pages | 2408 |
Hematology: Basic Principles and Practice, 7th Edition, is a comprehensive textbook that presents scientific foundations alongside clinical guidance. The volume is structured to support diagnostic and therapeutic problem-solving across the breadth of modern hematology.
Core subject areas span basic cellular and molecular biology, non-malignant blood conditions, and malignant disorders. The text examines gene expression, the mechanisms of normal hematopoiesis, red blood cell disorders, and clinical management strategies for acute leukemias and lymphomas across pediatric and adult populations.
Drawing on contributions from international subspecialists, the work incorporates digital tools to support pathology study, including a Virtual Microscope that allows high-magnification viewing of hematopathology slides.
Table of Contents
Chapter 1: Anatomy and Physiology of the Gene
Chapter 2: Epigenetics and Epigenomics
Chapter 3: Genomic Approaches to Hematology
Chapter 4: Regulation of Gene Expression, Transcription, Splicing and RNA Metabolism
Chapter 5: Protein Synthesis, Processing, and Trafficking
Chapter 6: Protein Architecture: Relationship of Form and Function
Chapter 7: Signaling Transduction and Metabolomics
Chapter 8: Pharmacogenomics and Hematologic Diseases
Chapter 9: Hematopoietic Stem Cell Biology
Chapter 10: Stem Cell Model of Hematologic Malignancies
Chapter 11: Hematopoietic Microenvironment
Chapter 12: Cell Adhesion
Chapter 13: Hematopoietic Cell Trafficking and Chemokines
Chapter 14: Interactions between Hematopoietic Stem and Progenitor Cells and the Bone Marrow: Current Biology of Stem Cell Homing and Mobilization
Chapter 15: Vascular Growth in Health and Disease
Chapter 16: Cytokine/Receptor families and signal transduction
Chapter 17: Control of Cell Division
Chapter 18: Cell Death
Chapter 19: Overview and Compartmentalization of the Immune System
Chapter 20: B-Cell Development
Chapter 21: T-Cell Immunity
Chapter 22: Natural Killer Cell Immunity
Chapter 23: Dendritic Cell Biology
Chapter 24: Complement and Immunoglobulin biology leading to clinical translation
Chapter 25: Tolerance and Autoimmunity
Chapter 26: Biology of Erythropoiesis, Erythroid Differentiation, and Maturation
Chapter 27: Granulocytopiesis and Monocytopoiesis
Chapter 28: Thrombocytopoiesis
Chapter 29: Inherited Forms of Bone Marrow Failure
Chapter 30: Aplastic Anemia
Chapter 31: Paroxysmal Nocturnal Hemoglobinuria
Chapter 32: Acquired Disorders of Unilineage Blood Cell Production
Chapter 33: Pathobiology of the Human Erythrocyte and Its Hemoglobins
Chapter 34: Approach to Anemia in the Adult and Child
Chapter 35: Pathophysiology of Iron Homeostasis
Chapter 36: Disorders of Iron Metabolism: Iron Deficiency and Overload
Chapter 37: Anemia of Chronic Diseases
Chapter 38: Heme Biosynthesis and Its Disorders: Porphyrias and Sideroblastic Anemias
Chapter 39: Megaloblastic Anemias
Chapter 40: Thalassemia Syndromes
Chapter 41: Pathobiology of Sickle Cell Disease
Chapter 42: Sickle Cell Disease: Clinical Features and Management
Chapter 43: Hemoglobin Variants Associated with Hemolytic Anemia, Altered Oxygen Affinity, and Methemoglobinemias
Chapter 44: Red Blood Cell Enzymopathies
Chapter 45: Red Blood Cell Membrane Disorders
Chapter 46: Autoimmune Hemolytic Anemia
Chapter 47: Extrinsic Nonimmune Hemolytic Anemias
Chapter 48: Granulocytosis, Granulocytopenia, Monocytosis, and Monocytopenia
Chapter 49: Lymphocytosis, Lymphocytopenia, Hypergammaglobulinemia, and Hypogammaglobulinemia
Chapter 50: Disorders of Phagocyte Function
Chapter 51: Congenital Disorders of Lymphocyte Function
Chapter 52: Histiocytic Disorders
Chapter 53: Lysosomal Storage Diseases: Perspectives and Principles
Chapter 54: Infectious Mononucleosis and Other Epstein-Barr Virus-Associated Diseases
Chapter 55: Progress in the Classification of Hematopoietic and Lymphoid Neoplasms: Clinical Implications
Chapter 56: The CytoGenomic Basis of Hematological Malignancies
Chapter 57: Pharmacology and Molecular Mechanisms of Antineoplastic Agents for Hematologic Malignancies
Chapter 58: Pathobiology of Acute Myeloid Leukemia
Chapter 59: Clinical Manifestations and Treatment of Acute Myeloid Leukemia
Chapter 60: Myelodysplastic Syndromes: Biology and Treatment
Chapter 61: Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia and Myelodysplastic Syndrome in Adults
Chapter 62: Acute Myeloid Leukemia in Children
Chapter 63: Myelodysplastic Syndrome and Myeloproliferative Syndrome in Children
Chapter 64: Pathobiology of Acute Lymphoblastic Leukemia
Chapter 65: Clinical Manifestations and Treatment in Children of Acute Lymphoblastic Leukemia
Chapter 66: Acute Lymphocytic Leukemia in Adults
Chapter 67: Chronic Myeloid Leukemia
Chapter 68: The Polycythemias
Chapter 69: Essential Thrombocythemia
Chapter 70: Primary Myelofibrosis
Chapter 71: Eosinophilia, Eosinophil-Associated Diseases, Chronic Eosinophil Leukemia, and the Hypereosinophilic Syndromes
Chapter 72: Mast Cells and Systemic Mastocytosis
Chapter 73: The Pathologic Basis for the Classification of Non-Hodgkin and Hodgkin Lymphomas
Chapter 74: Origins of Hodgkin Disease
Chapter 75: Hodgkin Lymphoma: Clinical Manifestations, Staging, and Therapy
Chapter 76: Origins of Non-Hodgkin Lymphomas
Chapter 77: Chronic Lymphocytic Leukemia
Chapter 78: Hairy Cell Leukemia
Chapter 79: Clinical Manifestations and Treatment of Indolent Lymphomas: Marginal Zone Lymphomas (Extranodal/Malt, Splenic, and Nodal)
Chapter 80: Clinical Manifestations, Staging, and Treatment of Follicular Lymphoma
Chapter 81: Mantle Cell Lymphoma
Chapter 82: Diagnosis and Treatment of Diffuse Large B-Cell Lymphoma (DLBCL) and Burkitt Lymphoma (BL)
Chapter 83: Viral-Related Lymphomas
Chapter 84: Malignant Lymphomas in Childhood
Chapter 85: T-Cell Lymphomas
Chapter 86: Multiple Myeloma
Chapter 87: Waldenstrom Macroglobulinemia/Lymphoplasmacytic Lymphoma
Chapter 88: Immunoglobuin Light-Chain Amyloidosis (Primary Amyloidosis)
Chapter 89: Clinical Approach to Infections in the Compromised Host
Chapter 90: Psychosocial Aspects of Hematologic Disorders
Chapter 91: Pain Management and Antiemetic Therapy in Hematologic Disorders
Chapter 92: Palliative Care
Chapter 93: Late Complications of Hematologic Diseases and Their Therapies
Chapter 94: Overview and Historical Perspective of Current Cell-Based Therapies
Chapter 95: Practical Aspects of Hematologic Stem Cell Harvesting and Mobilization
Chapter 96: IND Enabling Processes for Cell-Based Therapies
Chapter 97: Graft Engineering and Cell Processing
Chapter 98: Principles of Cell-Based Genetic Therapies
Chapter 99: Mesenchymal Stromal Cells
Chapter 100: T Cell Therapy of Hematological Diseases
Chapter 101: NK Cell-Based Therapies
Chapter 102: Immune Checkpoint Blockade in Hematologic Malignancies
Chapter 103: Overview and Choice of Donor of Hematopoietic Stem Cell Transplantation
Chapter 104: Indications and Outcomes of Allogeneic Hematopoietic Cell Transplantation for Hematologic Malignancies in Adults
Chapter 105: Unrelated Donor Hematopoietic Cell Transplantation
Chapter 106: Haploidentical Hematopoietic Cell Transplantation
Chapter 107: Unrelated Donor Cord Blood Transplantation for Hematologic Malignancies
Chapter 108: Graft-versus-Host Disease and Graft-versus-Leukemia Responses: Biology and Therapy
Chapter 109: Complications after Hematopoietic Cell Transplantation
Chapter 110: Human Blood Group Antigens and Antibodies
Chapter 111: Principles of Red Blood Cell Transfusion
Chapter 112: Clinical Considerations in Platelet Transfusion Therapy
Chapter 113: Human Leukocyte Antigen and Human Neutrophil Antigen Systems
Chapter 114: Principles of Neutrophil (Granulocyte) Transfusions
Chapter 115: Transfusion of Plasma Derivatives: Plasma, Cryoprecipitate, Albumin, and Immunoglobulins
Chapter 116: Preparation of Plasma-Derived and Recombinant Human Plasma Proteins
Chapter 117: Transfusion Therapy for Coagulation Factor Deficiencies
Chapter 118: Hemapheresis
Chapter 119: Transfusion Reactions to Blood and Cell Therapy Products
Chapter 120: Transfusion-Transmitted Diseases
Chapter 121: Pediatric Transfusion Medicine
Chapter 122: Overview of Hemostasis and Thrombosis
Chapter 123: The Blood Vessel Wall
Chapter 124: Megakaryocyte and Platelet Structure
Chapter 125: Molecular Basis of Platelet Function
Chapter 126: Molecular Basis of Blood Coagulation
Chapter 127: Regulatory Mechanisms in Hemostasis
Chapter 128: Clinical Approach to the Patient with Bleeding or Bruising
Chapter 129: Laboratory Evaluation of Hemostatic and Thrombotic Disorders
Chapter 130: Acquired Disorders of Platelet Function
Chapter 131: Diseases of Platelet Number: Immune Thrombocytopenia, Neonatal Alloimmune Thrombocytopenia, and Posttransfusion Purpura
Chapter 132: Thrombocytopenia Caused by Platelet Destruction, Hypersplenism, or Hemodilution
Chapter 133: Heparin-Induced Thrombocytopenia
Chapter 134: Thrombotic Thrombocytopenic Purpura and the Hemolytic Uremic Syndromes
Chapter 135: Hemophilia A and B
Chapter 136: Inhibitors in Hemophilia A and B
Chapter 137: Rare Coagulation Factor Deficiencies
Chapter 138: Structure, Biology, and Genetics of Von Willebrand Factor
Chapter 139: Disseminated Intravascular Coagulation
Chapter 140: Hypercoagulable States
Chapter 141: The Antiphospholipid Syndrome
Chapter 142: Venous Thromboembolism
Chapter 143: Mechanical Interventions in Arterial and Venous Thrombosis
Chapter 144: Atherothrombosis
Chapter 145: Stroke
Chapter 146: Acute Coronary Syndromes
Chapter 147: Atrial Fibrillation
Chapter 148: Peripheral Artery Disease
Chapter 149: Antithrombotic Drugs
Chapter 150: Disorders of Coagulation in the Neonate
Chapter 151: Hematologic Changes of Pregnancy
Chapter 152: Hematologic Manifestations of Childhood Illness
Chapter 153: Hematologic Manifestations of Systemic Disease: Liver Disease
Chapter 154: Hematologic Manifestations of Systemic Disease: Renal Disease
Chapter 155: Hematologic Manifestations of Cancer
Chapter 156: Integrated Therapies in Patients with Hematologic Diseases
Chapter 157: Hematologic Manifestations of AIDS
Chapter 158: Hematologic Manifestations of Parasitic Diseases
Chapter 159: Hematologic Problems in the Surgical Patient: Bleeding and Thrombosis
Chapter 160: The Spleen and Its Disorders
Chapter 161: Hematology in Aging
Chapter APPENDIX: Resources for the Hematologist: Interpretive Comments and Selected Reference Values for Neonatal, Pediatric, and Adult Populations
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