Iron in Clinical Practice
by Sue Pavord, Noemi Roy
1st Edition
Publisher: Wiley-Blackwell
Book Details
| Print ISBN | 9781394210886 |
| eText ISBN | 9781394210909 |
| Publisher | Wiley-Blackwell |
| Publishing Year | 2025 |
| Edition | 1st Edition |
| Language | English |
| Pages | 208 |
Iron in Clinical Practice, 1st Edition, provides a concise medical guide to human iron metabolism and the evaluation of iron disorders. Edited by Sue Pavord and Noemi Roy, the book equips medical professionals with essential knowledge for diagnosing and managing patient conditions marked by altered iron status.
The content synthesizes core biological processes, focusing on systemic iron homeostasis, biological iron trafficking, and the regulatory functions of hepcidin. Detailed clinical sections examine treatment options for restoring balance, focusing on oral iron supplementation and intravenous iron therapy.
Published by Wiley-Blackwell across 208 pages, this work delivers clear, evidence-based reference material. The text supports beginning and experienced clinicians who require actionable information for managing complex iron states in medical practice.
Table of Contents
Chapter 1: An Introduction to Iron in the Body
- • Introduction
- • Iron in the Body
- • Essential Functions of Iron in the Body
- • Iron Deficiency
- • Iron Overload
- • Bibliography
Chapter 2: Regulation of Iron Trafficking in the Body
- • Introduction
- • Hepcidin and Systemic Iron Homeostasis
- • Regulation of Hepcidin
- • Sensing Iron Concentrations
- • Erythropoietic Demand
- • Inflammation
- • Cellular Iron Homeostasis: Ferritin and Transferrin Receptor
- • Assessing Iron Status – How the Markers Used Relate to Underlying Biology
- • Bibliography
Chapter 3: Iron and Immunity
- • Introduction
- • The Battle for Iron and the Concept of ‘Nutritional Immunity’
- • Therapeutic Interventions Harnessing Nutritional Immunity
- • Iron Status and Susceptibility to Infections
- • Iron Deficiency and Health of Populations
- • Iron Overload and Risk of Infection
- • Iron Status and Response to Vaccines
- • Bibliography
Chapter 4: Impact of Iron Deficiency on the Individual
- • Introduction
- • Symptoms and Signs of Iron Deficiency
- • Impact of Iron Deficiency on Specific At-risk Groups
- • Pregnancy, Parturition and Lactation
- • Paediatric Population
- • Non-pregnant Premenopausal Women
- • Individuals from Resource-poor Settings
- • Other Clinical Situations Associated with Iron Deficiency
- • Gastrointestinal Bleeding
- • Heart Failure
- • Chronic Obstructive Airway Disease
- • Renal Disease
- • Conclusion
- • Bibliography
Chapter 5: Assessment of Iron Deficiency
- • Introduction
- • Definitions
- • Ferritin Thresholds
- • Inflammation and Liver Disease
- • Additional Biomarkers
- • Red Cell Indices
- • Hepcidin Levels
- • Conclusion
- • Bibliography
Chapter 6: Available Treatments for Iron Deficiency
- • Introduction
- • Oral Iron Supplementation
- • Administration of Oral Iron
- • Intravenous Iron Therapy
- • Potential Adverse Effects of Intravenous Iron
- • Individualising Treatment
- • Bibliography
Chapter 7: Iron Deficiency in Primary Care
- • Introduction
- • The Main Causes of Iron Deficiency in Primary Care
- • Pre-menopausal Women
- • Post-menopausal Women and Men
- • Older Adults
- • The Diagnosis of Iron Deficiency in Primary Care
- • Haemoglobin
- • Iron Studies
- • Further Investigations
- • Treatment of Iron Deficiency in Primary Care
- • Dietary Advice and Prevention of Future Iron Deficiency
- • Bibliography
Chapter 8: Iron Deficiency in the Preoperative Patient
- • Introduction
- • Haemoglobin Thresholds
- • Causes of Iron Deficiency in the Surgical Setting
- • Laboratory Tests
- • Management of Preoperative Iron Deficiency
- • Iron Treatment
- • Postoperative Management
- • Conclusion
- • Bibliography
Chapter 9: Iron Deficiency in Gastroenterology
- • Introduction
- • Gastrointestinal Causes of Iron Deficiency
- • Assessment of Iron Deficiency in Patients with Gastrointestinal Disease
- • Specific Gastrointestinal Investigations
- • Angiodysplasia
- • Treatment of Iron Deficiency in Patients with Gastrointestinal Disease
- • Bibliography
Chapter 10: Iron Deficiency in Renal Medicine
- • Introduction
- • Types of Iron Used in Nephrology and Safety Considerations
- • Iron Use in Haemodialysis Patients
- • Iron Use in Non-Dialysis-Dependent Chronic Kidney Disease
- • Iron Use in Peritoneal Dialysis
- • Bibliography
Chapter 11: Iron Deficiency in Cardiology
- • Introduction
- • Causes of Iron Deficiency in Heart Failure
- • Impact of Iron Deficiency in Heart Failure
- • Management of Iron Deficiency in Heart Failure
- • Diagnostic and Management Uncertainties in Individuals with Cardiac Disease
- • Current Definitions of Iron Deficiency
- • Current Iron Replacement Therapies
- • Bibliography
Chapter 12: Iron Deficiency in Neurology
- • Introduction
- • Iron Utilisation in the Central Nervous System
- • Iron and Neurocognitive Development
- • Neurological Associations in Iron Deficiency
- • Recommendations for Management of Iron Deficiency with Neurological Symptoms
- • Conclusion
- • Bibliography
Chapter 13: Iron Deficiency in Obstetrics
- • Introduction
- • The Maternal Effects of Iron Deficiency
- • Fetal Effects of Iron Deficiency
- • Defining Anaemia in Pregnancy
- • How Is Iron Deficiency Diagnosed in Pregnancy?
- • Indications for Intravenous Iron
- • Management of Postpartum Anaemia
- • Bibliography
Chapter 14: Iron Deficiency in Gynaecology
- • Introduction
- • Causes of Heavy Menstrual Bleeding
- • Definition of Heavy Menstrual Bleeding
- • Prevention of Iron Deficiency in Gynaecology
- • Investigation of Heavy Menstrual Bleeding
- • Management of Heavy Menstrual Bleeding
- • Hormonal Preparations
- • Anticoagulation Modification
- • Haemostatic Agents
- • Surgical Management
- • Iron Deficiency and Iron Deficiency Anaemia in Gynaecology
- • Impact of Iron Deficiency in Gynaecology
- • Management of Iron Deficiency in Women with Gynaecological Bleeding
- • Oral Iron Supplementation
- • Parenteral Iron Supplementation
- • Blood Transfusion
- • Bibliography
Chapter 15: Iron Deficiency in Orthopaedics
- • Introduction
- • Diagnosis
- • Aetiology of Iron Deficiency
- • Preoperative Treatment of Iron Deficiency Anaemia
- • Patient Outcomes
- • Iron Deficiency Without Anaemia
- • Bibliography
Chapter 16: Iron Deficiency in Intensive Care
- • Introduction
- • Iron Homeostasis in Critical Illness
- • Diagnosing Iron Deficiency in Critical Illness
- • Clinical Implications of Iron Deficiency in Intensive Care Unit
- • Patient Blood Management in Intensive Care
- • Intravenous Iron in Intensive Care
- • Concomitant Therapies for Anaemia Management in Intensive Care
- • Bibliography
Chapter 17: Iron Deficiency in Medical Oncology
- • Introduction
- • Causes of Anaemia in Patients with Cancer
- • Diagnosis of Iron Deficiency in Patients with Cancer
- • Management of Anaemia in Patients with Cancer
- • Erythropoiesis Stimulating Agents
- • Blood Transfusion in Oncology
- • Prevention of Anaemia in Patients with Cancer
- • Implementation of Local Policy
- • Novel Anti-anaemia Agents
- • Conclusion
- • Bibliography
Chapter 18: Transfusional Iron Overload
- • Introduction
- • The Causes of Iron Overload and Influencing Factors
- • Pathophysiology and Effects of Transfusional Iron Loading on Body Iron Distribution
- • Rates of Transfusional Iron Overloading and Distribution in Different Diseases
- • Consequences of Transfusional Iron Overload
- • Prevention of Transfusional Iron Overload
- • Bibliography
Chapter 19: Haemochromatosis
- • Introduction
- • Pathogenesis
- • Frequency and Penetrance of HFE-Related Haemochromatosis
- • Diagnosis
- • Treatment and Prevention
- • Bibliography
Chapter 20: Ineffective Erythropoiesis
- • Introduction
- • Erythropoiesis
- • The Role of Erythropoietin and Iron
- • Ferrokinetic Studies
- • Erythroferrone
- • Bibliography
Chapter 21: Iron Overload in the Heart
- • Iron and the Heart
- • Cardiac Iron Regulation
- • Iron Overload
- • Clinical Presentations and Their Management
- • Ventricular Dysfunction and Heart Failure
- • Arrhythmia
- • Assessment of Cardiac Iron
- • Magnetic Resonance Imaging
- • Other Heart Tests
- • Long-Term Management and Prevention
- • Bibliography
Chapter 22: Iron Overload and the Liver
- • Introduction
- • Histological Patterns of Hepatic Iron Overload
- • Pathophysiology of Hepatic Damage Secondary to Iron Overload
- • Assessment of Hepatic Iron Overload
- • Bibliography
Chapter 23: Impact of Iron Overload on the Endocrine System
- • Introduction
- • Diabetes Mellitus
- • Reproductive Endocrinology
- • Growth and Bone Health
- • Adrenal Function
- • Summary
- • Bibliography
Chapter 24: Iron Overload and the Musculoskeletal System
- • Introduction
- • Osteoporosis and Fracture Risk
- • Osteoarthritis
- • Calcium Pyrophosphate Deposition Disease
- • Management of Iron Overload in the Joints
- • Bibliography
Chapter 25: Assessment of Iron Overload
- • Introduction
- • Awareness of Potential Causes
- • Assessment of Transfusional Iron Overload
- • Role of Serum Ferritin and Iron Studies in Assessing Iron Overload
- • Imaging in Iron Overload
- • Monitoring Requirements for At-risk Patients
- • Bibliography
Chapter 26: Management of Iron Overload
- • Introduction
- • Iron Chelation Therapy
- • Indications for Iron Chelation Therapy
- • Administration of Iron Chelation Therapy
- • Combination Chelation
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