Hematology
Basic Principles and Practice
by Ronald Hoffman, Edward J. Benz, Leslie E. Silberstein, Helen Heslop, Jeffrey Weitz, Mohamed E. Salama
8th Edition
Publisher: Elsevier
Book Details
| Print ISBN | 9780323733885 |
| eText ISBN | 9780323733908 |
| Publisher | Elsevier |
| Publishing Year | 2022 |
| Edition | 8th Edition |
| Language | English |
| Pages | 2512 |
Hematology: Basic Principles and Practice, 8th Edition delivers a comprehensive clinical guide aimed at structuring diagnostic evaluation and treatment strategy for complex blood disorders. Published by Elsevier, this textbook supports practicing hematologists, practicing oncologists, vascular medicine specialists, and trainees in hematology, oncology, and vascular medicine programs.
The volume organizes pathophysiologic mechanisms into distinct thematic clinical areas to unify basic biological concepts with clinical patient care. Primary themes encompass molecular diagnostics, genomic approaches, hematopoietic cellular therapy, stem cell transplantation, anemia and iron homeostasis, disorders of phagocytes and lymphocytes, hemostasis, thrombosis, and hematologic malignancies.
Clinical decision-making algorithms integrated into the chapters guide practitioners when constructing diagnostic pathways and individualized treatment plans. Selected for the 2026 Doody's Core Titles in Hematology/Oncology, this edition provides practical support for specialized medical environments, fellowship training, and clinical decision-making.
Table of Contents
Chapter 1: Anatomy and Physiology of the Gene
Chapter 2: Epigenomics in Hematology
Chapter 3: Genomic Approaches to Hematology
Chapter 4: Regulation of Gene Expression in Hematology
Chapter 5: Genome Editing
Chapter 6: Signaling Transduction and Metabolomics
Chapter 7: Protein Architecture: Relationship of Form and Function
Chapter 8: Pharmacogenomics and Hematologic Diseases
Chapter 9: Hematopoietic Stem Cell Biology
Chapter 10: Mitochondria and Hematopoiesis
Chapter 11: Cytokines, Chemokines, Other Growth Factors, and Their Receptors
Chapter 12: Role of Chemokines in Leukocyte Trafficking
Chapter 13: Stem Cell Model of Hematologic Diseases
Chapter 14: Hematopoietic Microenvironment
Chapter 15: Cell Adhesion
Chapter 16: Current Biology of Stem Cell Homing and Mobilization: Dynamic Interactions Between Hematopoietic Stem and Progenitor Cells and Their Surrounding Bone Marrow Microenvironment
Chapter 17: Control of Cell Division
Chapter 18: Cell Death
Chapter 19: Aging and Hematopoiesis
Chapter 20: Dendritic Cell Biology
Chapter 21: Natural Killer Cell Immunity and Therapy
Chapter 22: B-Cell Development
Chapter 23: Complement and Immunoglobulin Biology Leading to Clinical Translation
Chapter 24: T-Cell Immunity
Chapter 25: Unmodified Ex Vivo Expanded T Cells
Chapter 26: Treatment of Hematologic Malignancies with Genetically Modified T Cells
Chapter 27: Biology of Erythropoiesis, Erythroid Differentiation, and Maturation
Chapter 28: Granulocytopoiesis and Monocytopoiesis
Chapter 29: Thrombocytopoiesis
Chapter 30: Inherited Bone Marrow Failure Syndromes
Chapter 31: Aplastic Anemia
Chapter 32: Paroxysmal Nocturnal Hemoglobinuria
Chapter 33: Acquired Disorders of Red Cell, White Cell, and Platelet Production
Chapter 34: Pathobiology of the Human Erythrocyte and Its Hemoglobins
Chapter 35: Approach to Anemia in the Adult and Child
Chapter 36: Iron Homeostasis and Its Disorders
Chapter 37: Disorders of Iron Homeostasis: Iron Deficiency and Overload
Chapter 38: Anemia of Chronic Inflammation
Chapter 39: Heme Biosynthesis and Its Disorders: Porphyrias and Sideroblastic Anemias
Chapter 40: Megaloblastic Anemias
Chapter 41: Thalassemia Syndromes
Chapter 42: Pathobiology of Sickle Cell Disease
Chapter 43: Clinical Aspects of Sickle Cell Disease
Chapter 44: Hemoglobin Variants Associated with Hemolytic Anemia, Altered Oxygen Affinity, and Methemoglobinemias
Chapter 45: Red Blood Cell Enzymopathies
Chapter 46: Red Blood Cell Membrane Disorders
Chapter 47: Autoimmune Hemolytic Anemia
Chapter 48: Extrinsic Nonimmune Hemolytic Anemias
Chapter 49: Neutrophilic Leukocytosis, Neutropenia, Monocytosis, and Monocytopenia
Chapter 50: Lymphocytosis, Lymphocytopenia, Hypergammaglobulinemia, and Hypogammaglobulinemia
Chapter 51: Disorders of Phagocyte Function
Chapter 52: Congenital Disorders of Lymphocyte Function
Chapter 53: Pediatric and Adult Histiocytic Disorders
Chapter 54: Lysosomal Storage Diseases, Focusing on Gaucher Disease: Perspectives and Principles
Chapter 55: Epstein-Barr Virus and Associated Lymphoproliferative Conditions
Chapter 56: Progress in the Classification of Hematopoietic and Lymphoid Neoplasms: Clinical Implications
Chapter 57: Conventional and Molecular Cytogenomic Basis of Hematologic Malignancies
Chapter 58: Pharmacology and Molecular Mechanisms of Antineoplastic Agents for Hematologic Malignancies
Chapter 59: Pathobiology of Acute Myeloid Leukemia
Chapter 60: Clinical Manifestations and Treatment of Acute Myeloid Leukemia
Chapter 61: Myelodysplastic Syndromes
Chapter 62: Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia and Myelodysplastic Syndrome in Adults
Chapter 63: Acute Myeloid Leukemia in Children
Chapter 64: Blastic Plasmacytoid Dendritic Cell Neoplasm
Chapter 65: Myelodysplastic Syndromes and Myeloproliferative Neoplasms in Children
Chapter 66: Pathobiology of Acute Lymphoblastic Leukemia
Chapter 67: Clinical Manifestations and Treatment of Childhood Acute Lymphoblastic Leukemia
Chapter 68: Acute Lymphoblastic Leukemia in Adults
Chapter 69: Chronic Myeloid Leukemia
Chapter 70: The Polycythemias
Chapter 71: Essential Thrombocythemia
Chapter 72: Primary Myelofibrosis and Chronic Neutrophilic Leukemia
Chapter 73: Myelodysplastic Syndrome/Myeloproliferative Neoplasm Overlap Syndromes
Chapter 74: Eosinophilia, Eosinophilic Neoplasms, and the Hypereosinophilic Syndromes
Chapter 75: Mast Cells and Mastocytosis
Chapter 76: Chronic Lymphocytic Leukemia
Chapter 77: Hairy Cell Leukemia
Chapter 78: The Pathologic Basis for the Classification of Non-Hodgkin and Hodgkin Lymphomas
Chapter 79: Origin of Hodgkin Lymphoma and Therapeutic Targets
Chapter 80: Hodgkin Lymphoma
Chapter 81: Origin of Non-Hodgkin Lymphoma and Therapeutic Targets
Chapter 82: Clinical Manifestations, Staging, and Treatment of Follicular Lymphoma
Chapter 83: Marginal Zone Lymphomas (Extranodal/MALT, Splenic, and Nodal)
Chapter 84: Diffuse Large B-Cell Lymphoma of the Central Nervous System
Chapter 85: High-Grade B-Cell Lymphomas
Chapter 86: Mantle Cell Lymphoma
Chapter 87: Virus-Associated Lymphoma
Chapter 88: Malignant Lymphomas in Childhood
Chapter 89: T-Cell Lymphomas
Chapter 90: Monoclonal Gammopathy of Undetermined Significance and Smoldering Multiple Myeloma
Chapter 91: Multiple Myeloma
Chapter 92: Waldenström Macroglobulinemia/Lymphoplasmacytic Lymphoma
Chapter 93: Immunoglobulin Light-Chain Amyloidosis (Primary Amyloidosis)
Chapter 94: Key Considerations for Managing Infections in the Compromised Host
Chapter 95: Principles of Radiation Therapy for Hematologic Disease
Chapter 96: Grading and Toxicity Management after Immune Effector Therapy
Chapter 97: Identification and Management of Checkpoint Inhibition Toxicity
Chapter 98: Psychosocial Aspects of Hematologic Disorders
Chapter 99: Pain Management and Antiemetic Therapy in Hematologic Disorders
Chapter 100: Palliative Care
Chapter 101: Therapy-related Late Effects of Hematologic Malignancies
Chapter 102: Practical Aspects of Hematopoietic Stem Cell Harvesting and Mobilization
Chapter 103: Graft Engineering and Cell Processing
Chapter 104: Principles of Cell-Based Genetic Therapies
Chapter 105: Indications, Outcomes, and Donor Selection for Allogeneic Hematopoietic Cell Transplantation for Hematologic Malignancies in Adults
Chapter 106: Unrelated Donor Hematopoietic Cell Transplantation
Chapter 107: Haploidentical Hematopoietic Stem Cell Transplantation
Chapter 108: Cord Blood Transplantation
Chapter 109: Graft-versus-Host Disease and Graft-versus- Leukemia Responses
Chapter 110: Supportive Care for the Transplant Patient
Chapter 111: Human Blood Group Antigens and Antibodies
Chapter 112: Principles of Red Blood Cell Transfusion
Chapter 113: Clinical Considerations in Platelet Transfusion Therapy
Chapter 114: Human Leukocyte Antigen and Human Neutrophil Antigen Systems
Chapter 115: Principles of Plasma and Plasma Derivatives
Chapter 116: Hemapheresis
Chapter 117: Transfusion Reactions to Blood and Hematopoietic Stem Cell Therapy Products
Chapter 118: Transfusion-Transmitted Diseases
Chapter 119: Pediatric Transfusion Medicine
Chapter 120: Transfusion and Apheresis Support for Sickle Cell Disease Patients
Chapter 121: Overview of Hemostasis and Thrombosis
Chapter 122: Blood Vessels
Chapter 123: Megakaryocyte and Platelet Structure
Chapter 124: Molecular Basis of Platelet Function
Chapter 125: Molecular Basis of Blood Coagulation
Chapter 126: Evaluation of the Patient with Suspected Bleeding Disorders
Chapter 127: Laboratory Evaluation of Hemostatic and Thrombotic Disorders
Chapter 128: Acquired Disorders of Platelet Function
Chapter 129: Diseases of Platelet Number: Immune Thrombocytopenia, Neonatal Alloimmune Thrombocytopenia, and Posttransfusion Purpura
Chapter 130: Thrombocytopenia Caused by Hypersplenism, Platelet Destruction, or Surgery/Hemodilution
Chapter 131: Heparin-Induced Thrombocytopenia
Chapter 132: Thrombotic Thrombocytopenic Purpura and the Hemolytic Uremic Syndromes
Chapter 133: Structure, Biology, and Genetics of von Willebrand Factor
Chapter 134: Hemophilia A and B
Chapter 135: Rare Coagulation Factor Deficiencies
Chapter 136: Transfusion Therapy for Coagulation Factor Deficiencies
Chapter 137: Disseminated Intravascular Coagulation
Chapter 138: Hypercoagulable States
Chapter 139: Antiphospholipid Syndrome
Chapter 140: Venous Thromboembolism
Chapter 141: Prevention and Treatment of Venous Thromboembolism in Pregnancy
Chapter 142: Atherothrombosis
Chapter 143: Antithrombotic Drugs
Chapter 144: Stroke
Chapter 145: Acute Coronary Syndromes
Chapter 146: Peripheral Artery Disease
Chapter 147: Atrial Fibrillation
Chapter 148: Bleeding and Clotting Disorders in Pediatrics
Chapter 149: Hematologic Changes in Pregnancy
Chapter 150: Hematologic Manifestations of End-Organ Failure
Chapter 151: Hematologic Manifestations of Solid Tumors
Chapter 152: Hematologic Manifestations of HIV/AIDS
Chapter 153: Hematologic Findings and Consequences of Novel Coronavirus (SARS-CoV-2) Infection
Chapter 154: Hematologic Aspects of Parasitic Diseases
Chapter 155: Hematologic Problems in the Surgical Patient: Bleeding and Thrombosis
Chapter 156: The Spleen and Its Disorders
Chapter 157: Aging and Hematologic Disorders
Chapter 158: Onco-cardiology: Focus on Cardiac Complications of Hematologic Treatments
Chapter 159: Resources for the Hematologist: Interpretive Comments and Selected Reference Values for Neonatal, Pediatric, and Adult Populations 2408.e1
Chapter 160: can be found online at Elsevier eBooks for Practicing Clinicians
Customer Reviews
0.0
0 reviews
No reviews yet. Be the first to review this book!
Write a Review
Reviewed by GradeFocus Editorial Team
▶Research Sources (13)
- Unlimited Hematology: Basic Principles and Practice, Eighth Edition ...
- Sourcebooks, LLC.
- Hematology : Basic Principles and Practice, Eighth Edition Ronald ...
- Please verify you are human - Captcha
- Untitled
- Page 4 | Hematology Books, eBooks & Journals | US Elsevier Health
- When you're a romance writer and the venue's electrical system goes up in ...
- Study Guides, Test Preparation & More - Books-A-Million
- Hematology - 9780323733885 - US Elsevier Health
- Hematology - 8th Edition | Elsevier Shop
- ISBN 9780323733885 - Hematology Basic Principles and Practice ...
- Hematology, 8th Edition - 9780323733885 - Elsevier
- Hematology - Edition 8 - Edited by Ronald Hoffman, MD, Edward ...
