Kinase Targets and Drug Discovery
by Xiaoyun Lu
1st Edition
Publisher: Academic Press
Book Details
| Print ISBN | 9780443439742 |
| eText ISBN | 9780443439759 |
| Publisher | Academic Press |
| Publishing Year | 2026 |
| Edition | 1st Edition |
| Language | English |
| Pages | 374 |
Kinase Targets and Drug Discovery, 1st Edition provides pharmacologists, medicinal chemists, and research professionals with a systematic overview of protein kinase biology and therapeutic development. The text explains how kinase signaling regulates fundamental cellular functions while establishing practical methods to address modern challenges in kinase inhibitor discovery.
The volume synthesizes technical methodologies across distinct analytical and structural domains. It integrates high-throughput screening approaches and computational methods with specialized chemical strategies, including covalent modifiers, small macrocycle structures, and allosteric binding mechanisms. These technical frameworks connect direct catalytic modulation to therapeutic applications in cancer treatment and immuno-oncology.
Published within the Drug Discovery Opinions series from Academic Press, this 374-page work incorporates recent insights into artificial intelligence techniques and novel therapeutic modalities such as targeted kinase degraders. Academic scholars and industrial research teams can utilize these structured frameworks to evaluate target mechanisms, refine screening methods, and advance small-molecule discovery pipelines.
Table of Contents
Chapter 1: Introduction to kinases and their functions
Chapter 2: Kinase inhibitors in diseases therapy
Chapter 3: Challenges in kinase inhibitors discovery
Chapter 4: Screening approaches for kinases
Chapter 5: Computational approaches for kinase inhibitors
Chapter 6: Covalent inhibitors of kinases
Chapter 7: Small macrocyclic inhibitors of kinase
Chapter 8: Allosteric targeting of protein kinases: mechanisms and computational design strategies
Chapter 9: Kinase degrader: a new era of drug development
Chapter 10: Small-molecule kinase activators
Chapter 11: Kinase inhibitors as anticancer drugs
Chapter 12: Kinase inhibition for nononcologic diseases
Chapter 13: Kinase inhibition for noncatalytic function
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