
Kratom
History, Science and Therapeutic Potential
by Jack E. Henningfield, Chad E. Beyer, Robert B. Raffa
1st Edition
Publisher: Academic Press
Book Details
| Print ISBN | 9780443274121 |
| eText ISBN | 9780443274138 |
| Publisher | Academic Press |
| Publishing Year | 2025 |
| Edition | 1st Edition |
| Language | English |
| Pages | 262 |
Kratom: History, Science and Therapeutic Potential, 1st Edition, provides a comprehensive scientific analysis of Mitragyna speciosa for healthcare providers, general practitioners, and addiction researchers. The publication addresses critical knowledge needs surrounding the plant, focusing on its dual presentation of weak opioid and stimulant effects in contemporary settings.
The volume surveys the botanical features, geographic distribution, and phytochemistry of Mitragyna speciosa alongside its historical scientific evolution. It details chemical properties, primary metabolites, and ADME profiles while examining physical dependence and addiction mechanisms. The text also reviews evidence regarding potential therapeutic applications for depression, attention deficit hyperactivity disorder, post-traumatic stress disorder, and opioid use disorder.
By combining phytochemical data with clinical pharmacological perspectives, the book supports central nervous system drug developers and regulatory scholars evaluating botanical materials. This volume offers structured reference material to guide research, clinical inquiry, and evidence-based practice across related scientific disciplines.
Table of Contents
Chapter 1: Botany, geographical distribution, and phytochemistry of Mitragyna speciosa(Korth.) and related species
Chapter 2: The scientific evolution of kratom: a historical overview
Chapter 3: Recent patterns and reasons for use
Chapter 4: Chemistry and metabolites: ADME
Chapter 5: Kratom-related physical dependence and addiction
Chapter 6: Current therapeutic uses
Chapter 7: Regulation and policy regarding kratom-derived dietary supplements and direct-to-consumer sales
Chapter 8: Patentability and exclusivity of kratom based natural products
Chapter 9: Kratom drug–drug (and other) interactions
Chapter 10: Susceptible populations
Chapter 11: Kratom purity and quality control issues: an in-depth analysis
Chapter 12: Kratom entrepreneurship | exploiting the commercial potential of kratom and its active alkaloids
Chapter 13: Equity investment into kratom, mitragynine, and related products
Chapter 14: Medical marijuana as a template for understanding kratom
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