Targeting Enzymes in the Brain

Targeting Enzymes in the Brain, 1st Edition, edited by Takashi Tsukamoto, is an academic reference volume dedicated to central nervous system enzymatic targets and pharmacological drug development. Published by Academic Press as Volume 102 in the Advances in Pharmacology series, this publication outlines current research methodologies and structural insights for academic specialists in the field.

The text evaluates specific biological pathways through distinct thematic reviews. Chapters examine phosphodiesterase functionality, PAAN/MIF nuclease properties, and glutamate carboxypeptidase II mechanisms, alongside focused assessments of the prolyl hydroxylase domain. Each section clarifies essential molecular interactions that govern enzymatic behavior in neural tissue.

Additionally, the volume outlines drug discovery strategies for TAK-418, a specific LSD1 enzyme inhibitor evaluated as a therapy for autism. The work provides a direct reference for researchers and upper-level students pursuing specialized scientific investigation within brain enzyme research and neuropharmacology.